Granzyme-B expression by T- and B- cells during severe AQP4-positive neuromyelitis optica spectrum disorder with fatal venous thromboembolism outcome
Vinícius Oliveira Boldrini, Mariana Rabelo Brito, Raphael Patrício Silva Quintiliano, Lucas Scárdua Silva, Clarissa Lin Yasuda, Fernando Cendes, Alessandro Santos Farias, Alfredo Damasceno
ARTIGO
Inglês
[Case report]
Agradecimentos: This study was supported by the São Paulo Research Foundation (FAPESP) (grant numbers: 2013/07559-3; 2017/21363-5), the National Council for Scientific and Technological Development (CNPQ) (grant number: 315953/2021-7), the Coordination for the Improvement of Higher Education...
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Agradecimentos: This study was supported by the São Paulo Research Foundation (FAPESP) (grant numbers: 2013/07559-3; 2017/21363-5), the National Council for Scientific and Technological Development (CNPQ) (grant number: 315953/2021-7), the Coordination for the Improvement of Higher Education Personnel (CAPES) (Finance Code 001), and the European Charcot Foundation (ECF) (Fellow Community Small Grant Fund)
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Abstract: The expression of serine protease granzyme-B (GzmB) by circulating CD8+ T lymphocytes has been recently suggested as a biomarker for poor immunotherapy response and severe disability in patients with Neuromyelitis Optica spectrum disorders (NMOSD). In parallel, venous thromboembolism (VTE)...
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Abstract: The expression of serine protease granzyme-B (GzmB) by circulating CD8+ T lymphocytes has been recently suggested as a biomarker for poor immunotherapy response and severe disability in patients with Neuromyelitis Optica spectrum disorders (NMOSD). In parallel, venous thromboembolism (VTE) has been reported mainly in NMOSD patients exhibiting transverse myelitis. Case presentation: Here, we describe an Aquaporin-4 positive (AQP4-positive) NMOSD patient who showed short myelitis (SM) and experienced a fatal pulmonary thromboembolism/lower extremity deep vein thrombosis during anti-CD20 treatment. Flow cytometry analyses from the peripheral blood revealed an enhanced cytotoxic behavior through circulating CD8+GzmB+ T, CD4+GzmB+ T lymphocytes, and residual CD19+GzmB+ B cells. Fatal VTE may be a rare outcome, particularly in patients exhibiting SM, and may share poorly understood immunological mechanisms with AQP4-positive NMOSD severity
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2013/07559-3; 2017/21363-5
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
315953/2021-7
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
001
Aberto
Cendes, Fernando, 1962-
Autor
Granzyme-B expression by T- and B- cells during severe AQP4-positive neuromyelitis optica spectrum disorder with fatal venous thromboembolism outcome
Vinícius Oliveira Boldrini, Mariana Rabelo Brito, Raphael Patrício Silva Quintiliano, Lucas Scárdua Silva, Clarissa Lin Yasuda, Fernando Cendes, Alessandro Santos Farias, Alfredo Damasceno
Granzyme-B expression by T- and B- cells during severe AQP4-positive neuromyelitis optica spectrum disorder with fatal venous thromboembolism outcome
Vinícius Oliveira Boldrini, Mariana Rabelo Brito, Raphael Patrício Silva Quintiliano, Lucas Scárdua Silva, Clarissa Lin Yasuda, Fernando Cendes, Alessandro Santos Farias, Alfredo Damasceno
Fontes
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Frontiers in neurology v. 14, n. art. 1208977, 2023 |