TAM and TIM receptors mRNA expression in Zika virus infected placentas
Guilherme M. Nobrega, Ana Paula Samogim, Pierina L. Parise, Emanuella M. Venceslau, José Paulo S. Guida, Rodolfo R. Japecanga, Mariene R. Amorim, Daniel A. Toledo-Teixeira, Julia Forato, Sílvio R. Consonni, Maria Laura Costa, José Luiz Proenca-Modena, Eliana Amaral, Helaine Maria Besteti Pires...
Guilherme M. Nobrega, Ana Paula Samogim, Pierina L. Parise, Emanuella M. Venceslau, José Paulo S. Guida, Rodolfo R. Japecanga, Mariene R. Amorim, Daniel A. Toledo-Teixeira, Julia Forato, Sílvio R. Consonni, Maria Laura Costa, José Luiz Proenca-Modena, Eliana Amaral, Helaine Maria Besteti Pires Mayer-Milanez, Carolina C. Ribeiro-do-Valle, Roseli Calil, João Renato Bennini Junior, Giuliane Jesus Lajos, Albina Altemani, Maria Luiza Moretti, Mariangela Ribeiro Resende, Márcia Teixeira Garcia, Rodrigo Nogueira Angerami, Marcos Tadeu Nolasco da Silva, Ana Carolina Coan, Maria Francisca Colella-Santos, Andrea Paula Bruno von Zuben, André Ricardo Ribas Freitas, Marco Aurélio Ramirez Vinolo, Rodrigo Ramos Catharino, Fábio Trindade Maranhão Costa, Clarice Weis Arns, Aline Vieira, Gabriela Fabiano de Souza, Karina Bispo dos Santos, Mariene Ribeiro Amorim, Matheus Cavalheiro Martini, Stéfanie Primon Muraro
ARTIGO
Inglês
Agradecimentos: This study was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) [grant number 2016/00194-8]. GMN was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) [grant number 119172/2018-6] and is currently supported by FAPESP [grant...
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Agradecimentos: This study was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) [grant number 2016/00194-8]. GMN was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) [grant number 119172/2018-6] and is currently supported by FAPESP [grant number 19/18720-6]. APS was supported by the UNICAMP Student Aid System. PLP has FAPESP support [grant number 2017/26908-0]. EMV is supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) [grant number 88882.329828/2019]. MLC has CNPq support [grant number 409605/2016-6] and FAEPEX [grant number 2965/19]. DATT was supported by FAPESP [grant number 2017/02402-0] and CNPq [grant number 141844/2019-1]. PLP and JF were supported by FAPESP [grant numbers 2017/26908-0 and 2017/22062-9, respectively]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of this manuscript.
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Abstract: To investigate the role of TYRO3, AXL and TIM1 receptors in the Zika virus (ZIKV) cycle, we determined their mRNA expression in different placental sites of ZIKV infected tissue during pregnancy. Unexpectedly, the ZIKV infection was not related with mRNA upregulation of these receptors or...
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Abstract: To investigate the role of TYRO3, AXL and TIM1 receptors in the Zika virus (ZIKV) cycle, we determined their mRNA expression in different placental sites of ZIKV infected tissue during pregnancy. Unexpectedly, the ZIKV infection was not related with mRNA upregulation of these receptors or changes in expression of type I and III interferons in different placental sites. Instead, a decrease of TYRO3 mRNA expression was observed in positive sites of ZIKV positive placentas in comparison to negative sites. The basis of this downregulation can help to understand how ZIKV persists in placental tissue during pregnancy
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2016/00194-8; 2017/26908-0; 2017/02402-0; 2017/22062-9; 2019/18720-6
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
409605/2016-6; 119172/2018-6; 141844/2019-1
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
88882.329828/2019
Aberto
Japecanga, Rodolfo Rosa
Autor
Forato, Julia, 1996
Autor
Calil, Roseli
Autor
Garcia, Márcia Teixeira
Autor
Vieira, Aline, 1989-
Autor
TAM and TIM receptors mRNA expression in Zika virus infected placentas
Guilherme M. Nobrega, Ana Paula Samogim, Pierina L. Parise, Emanuella M. Venceslau, José Paulo S. Guida, Rodolfo R. Japecanga, Mariene R. Amorim, Daniel A. Toledo-Teixeira, Julia Forato, Sílvio R. Consonni, Maria Laura Costa, José Luiz Proenca-Modena, Eliana Amaral, Helaine Maria Besteti Pires...
Guilherme M. Nobrega, Ana Paula Samogim, Pierina L. Parise, Emanuella M. Venceslau, José Paulo S. Guida, Rodolfo R. Japecanga, Mariene R. Amorim, Daniel A. Toledo-Teixeira, Julia Forato, Sílvio R. Consonni, Maria Laura Costa, José Luiz Proenca-Modena, Eliana Amaral, Helaine Maria Besteti Pires Mayer-Milanez, Carolina C. Ribeiro-do-Valle, Roseli Calil, João Renato Bennini Junior, Giuliane Jesus Lajos, Albina Altemani, Maria Luiza Moretti, Mariangela Ribeiro Resende, Márcia Teixeira Garcia, Rodrigo Nogueira Angerami, Marcos Tadeu Nolasco da Silva, Ana Carolina Coan, Maria Francisca Colella-Santos, Andrea Paula Bruno von Zuben, André Ricardo Ribas Freitas, Marco Aurélio Ramirez Vinolo, Rodrigo Ramos Catharino, Fábio Trindade Maranhão Costa, Clarice Weis Arns, Aline Vieira, Gabriela Fabiano de Souza, Karina Bispo dos Santos, Mariene Ribeiro Amorim, Matheus Cavalheiro Martini, Stéfanie Primon Muraro
TAM and TIM receptors mRNA expression in Zika virus infected placentas
Guilherme M. Nobrega, Ana Paula Samogim, Pierina L. Parise, Emanuella M. Venceslau, José Paulo S. Guida, Rodolfo R. Japecanga, Mariene R. Amorim, Daniel A. Toledo-Teixeira, Julia Forato, Sílvio R. Consonni, Maria Laura Costa, José Luiz Proenca-Modena, Eliana Amaral, Helaine Maria Besteti Pires...
Guilherme M. Nobrega, Ana Paula Samogim, Pierina L. Parise, Emanuella M. Venceslau, José Paulo S. Guida, Rodolfo R. Japecanga, Mariene R. Amorim, Daniel A. Toledo-Teixeira, Julia Forato, Sílvio R. Consonni, Maria Laura Costa, José Luiz Proenca-Modena, Eliana Amaral, Helaine Maria Besteti Pires Mayer-Milanez, Carolina C. Ribeiro-do-Valle, Roseli Calil, João Renato Bennini Junior, Giuliane Jesus Lajos, Albina Altemani, Maria Luiza Moretti, Mariangela Ribeiro Resende, Márcia Teixeira Garcia, Rodrigo Nogueira Angerami, Marcos Tadeu Nolasco da Silva, Ana Carolina Coan, Maria Francisca Colella-Santos, Andrea Paula Bruno von Zuben, André Ricardo Ribas Freitas, Marco Aurélio Ramirez Vinolo, Rodrigo Ramos Catharino, Fábio Trindade Maranhão Costa, Clarice Weis Arns, Aline Vieira, Gabriela Fabiano de Souza, Karina Bispo dos Santos, Mariene Ribeiro Amorim, Matheus Cavalheiro Martini, Stéfanie Primon Muraro
Fontes
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Placenta Vol. 101 (Nov., 2020), p. 204-207 |