Oral and oropharyngeal diffuse large B-cell lymphoma and high-grade B-cell lymphoma : a clinicopathologic and prognostic study of 69 cases
Carla Isabelly Rodrigues-Fernandes, Arnaldo Gonçalves Junior, Ciro Dantas Soares, Thayná Melo de Lima Morais, Gleyson Kleber do Amaral-Silva, Maria Goretti Freire de Carvalho, Lucas Lacerda de Souza, Fábio Ramôa Pires, Teresa Cristina Ribeiro Bartholomeu dos Santos, Débora Lima Pereira, Luis...
Carla Isabelly Rodrigues-Fernandes, Arnaldo Gonçalves Junior, Ciro Dantas Soares, Thayná Melo de Lima Morais, Gleyson Kleber do Amaral-Silva, Maria Goretti Freire de Carvalho, Lucas Lacerda de Souza, Fábio Ramôa Pires, Teresa Cristina Ribeiro Bartholomeu dos Santos, Débora Lima Pereira, Luis Fernando Rivero, Kelly Tambasco Bezerra, Bruno Augusto Benevenuto de Andrade, Mário José Romañach, Michele Agostini, Javier Rendón Henao, Amanda de Farias Gabriel, Décio dos Santos Pinto Júnior, Manoela Domingues Martins, Mateus José de Carvalho Pereira, Ricardo Alves Mesquita, Ricardo Santiago Gomez, Giovanna Ribeiro Souto, Alan Roger Santos-Silva, Pablo Agustin Vargas, Márcio Ajudarte Lopes, Oslei Paes de Almeida, Flávia Sirotheau Corrêa Pontes, Hélder Antônio Rebelo Pontes, Rommel Mario Rodríguez Burbano, Felipe Paiva Fonseca
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Inglês
Agradecimentos: This study was supported by grants from the São Paulo State Research Foundation (FAPESP), processes numbers 2017/14880-3 and 2017/08995-2, and by the Coordination for the Improvement of Higher Education Personnel (CAPES) finance code 001. This article is the product of an MSc...
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Agradecimentos: This study was supported by grants from the São Paulo State Research Foundation (FAPESP), processes numbers 2017/14880-3 and 2017/08995-2, and by the Coordination for the Improvement of Higher Education Personnel (CAPES) finance code 001. This article is the product of an MSc dissertation developed in the University of Campinas and a PhD thesis developed in the Federal University of Pará
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Abstract: The objective of this study was to describe the clinicopathological, molecular, and prognostic features of oral/oropharyngeal diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma. All cases were retrieved from 7 Brazilian institutions. Immunohistochemical reactions were...
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Abstract: The objective of this study was to describe the clinicopathological, molecular, and prognostic features of oral/oropharyngeal diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma. All cases were retrieved from 7 Brazilian institutions. Immunohistochemical reactions were performed to confirm the diagnoses and to categorize the tumors. In situ hybridization was used to detect Epstein-Barr virus (EBV) and fluorescence in situ hybridization was used to identify gene rearrangements. Most cases involved the oral cavity (76.8%). Males and females, with a mean age of 60 years, were evenly affected. Tumors mostly presented as painful swellings. Forty cases represented germinal center B-cell type (58%). Five cases presented double-hit translocation and 3 harbored rearrangement for MYC/BCL2/BCL6. EBV was detected in 3 cases (4.3%). The 5-year overall survival was 44.4%. Female sex, presence of pain and ulcer, microscopic "starry sky pattern" and necrosis, co-expression of c-Myc/Bcl2, and translocation of MYC were associated with a lower survival in univariate analysis (P = .05, P = .01, P = .01, P = .03, P = .05, P = .006, P = .05, respectively). Patients affected by oral/oropharyngeal DLBCL have a low survival rate. High-grade B-cell lymphoma (17.7%) and EBV-positive DLBCL, not otherwise specified (4.3%) account for a small number of cases
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2017/14880-3; 2017/08995-2
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
001
Fechado
Oral and oropharyngeal diffuse large B-cell lymphoma and high-grade B-cell lymphoma : a clinicopathologic and prognostic study of 69 cases
Carla Isabelly Rodrigues-Fernandes, Arnaldo Gonçalves Junior, Ciro Dantas Soares, Thayná Melo de Lima Morais, Gleyson Kleber do Amaral-Silva, Maria Goretti Freire de Carvalho, Lucas Lacerda de Souza, Fábio Ramôa Pires, Teresa Cristina Ribeiro Bartholomeu dos Santos, Débora Lima Pereira, Luis...
Carla Isabelly Rodrigues-Fernandes, Arnaldo Gonçalves Junior, Ciro Dantas Soares, Thayná Melo de Lima Morais, Gleyson Kleber do Amaral-Silva, Maria Goretti Freire de Carvalho, Lucas Lacerda de Souza, Fábio Ramôa Pires, Teresa Cristina Ribeiro Bartholomeu dos Santos, Débora Lima Pereira, Luis Fernando Rivero, Kelly Tambasco Bezerra, Bruno Augusto Benevenuto de Andrade, Mário José Romañach, Michele Agostini, Javier Rendón Henao, Amanda de Farias Gabriel, Décio dos Santos Pinto Júnior, Manoela Domingues Martins, Mateus José de Carvalho Pereira, Ricardo Alves Mesquita, Ricardo Santiago Gomez, Giovanna Ribeiro Souto, Alan Roger Santos-Silva, Pablo Agustin Vargas, Márcio Ajudarte Lopes, Oslei Paes de Almeida, Flávia Sirotheau Corrêa Pontes, Hélder Antônio Rebelo Pontes, Rommel Mario Rodríguez Burbano, Felipe Paiva Fonseca
Oral and oropharyngeal diffuse large B-cell lymphoma and high-grade B-cell lymphoma : a clinicopathologic and prognostic study of 69 cases
Carla Isabelly Rodrigues-Fernandes, Arnaldo Gonçalves Junior, Ciro Dantas Soares, Thayná Melo de Lima Morais, Gleyson Kleber do Amaral-Silva, Maria Goretti Freire de Carvalho, Lucas Lacerda de Souza, Fábio Ramôa Pires, Teresa Cristina Ribeiro Bartholomeu dos Santos, Débora Lima Pereira, Luis...
Carla Isabelly Rodrigues-Fernandes, Arnaldo Gonçalves Junior, Ciro Dantas Soares, Thayná Melo de Lima Morais, Gleyson Kleber do Amaral-Silva, Maria Goretti Freire de Carvalho, Lucas Lacerda de Souza, Fábio Ramôa Pires, Teresa Cristina Ribeiro Bartholomeu dos Santos, Débora Lima Pereira, Luis Fernando Rivero, Kelly Tambasco Bezerra, Bruno Augusto Benevenuto de Andrade, Mário José Romañach, Michele Agostini, Javier Rendón Henao, Amanda de Farias Gabriel, Décio dos Santos Pinto Júnior, Manoela Domingues Martins, Mateus José de Carvalho Pereira, Ricardo Alves Mesquita, Ricardo Santiago Gomez, Giovanna Ribeiro Souto, Alan Roger Santos-Silva, Pablo Agustin Vargas, Márcio Ajudarte Lopes, Oslei Paes de Almeida, Flávia Sirotheau Corrêa Pontes, Hélder Antônio Rebelo Pontes, Rommel Mario Rodríguez Burbano, Felipe Paiva Fonseca
Fontes
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Oral surgery, oral medicine, oral pathology and oral radiology Vol. 131, n. 4 (Apr., 2021), p. 452-462e.4 |