Immunoexpression of BDNF, TrkB, and p75NTR receptors in peripheral neural lesions of the head and neck
Julia Turra Ribeiro, Stéfanie Thieme, Paula Zettermann, Amanda Almeida Leite, Virgilio Gonzales Zanella, Emily Ferreira Salles Pilar, Felipe Paiva Fonseca, Ricardo Alves Mesquita, Pablo Agustin Vargas, Jean Nunes Santos, Manoela Domingues Martins
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Agradecimentos: The authors are grateful to Flavia Rejane Giusti for her technical support and the Biostatistics Unit of the Postgraduate Research Group of the Porto Alegre University Hospital for assisting the statistical analysis. The authors are also grateful to the CAPES (88887.31959/2019) for...
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Agradecimentos: The authors are grateful to Flavia Rejane Giusti for her technical support and the Biostatistics Unit of the Postgraduate Research Group of the Porto Alegre University Hospital for assisting the statistical analysis. The authors are also grateful to the CAPES (88887.31959/2019) for student scholarship. This study was funded by the Postgraduate Research Group of the Hospital de Clínicas de Porto Alegre (GPPG/FIPE: 2019-0185). Felipe Paiva Fonseca, Ricardo Alves Mesquita, Pablo Agustin Vargas, Jean Nunes dos Santos and Manoela Domingues Martins are research fellows funded by the Brazilian National Council for Scientific and Technological Development (CNPq)
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Abstract: Brain-derived neurotrophic factor (BDNF) and neurotrophin receptors have been recognized as fundamental regulators of normal brain development, homeostasis, and plasticity. They have also been studied in the behavior of central nervous system tumors. Here, we studied the pattern of BDNF,...
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Abstract: Brain-derived neurotrophic factor (BDNF) and neurotrophin receptors have been recognized as fundamental regulators of normal brain development, homeostasis, and plasticity. They have also been studied in the behavior of central nervous system tumors. Here, we studied the pattern of BDNF, TrkB and p75NTR immunoexpression in peripheral benign and malignant neural lesions in head and neck. This cross-sectional analytical study included 79 cases of head and neck neural lesions. Nineteen cases of traumatic neuromas (TN), 20 cases of granular cell tumors (GCT), 16 cases of neurofibromas (NF), 20 cases of schwannomas (SC), and 4 malignant peripheral nerve sheath tumor (MPNST) were submitted to immunohistochemistry with BDNF, TrkB, and p75NTR antibodies. A semi-quantitative analysis was performed. The analysis of BDNF demonstrated a high percentage of positive cells in TN, GCT and SC with a decrease in cases of NF and MPNST. TrkB presented a lower significant immunoexpression in GCT in relation to the TN, NF, SC, and MPNST (P < .0001); and TN showed less percentage of positive cell compared to SC (P = .0017). Regarding p75NTR, the percentage of positive cell was significantly reduced in MPNST compared GCT (P = .009), NF (P = .0138) and SC (P = .0069). Also, a decrease in TN compared to GCT (P = .007) was observed. Our results showed the immunoreactivity of BDNF, TrkB, and p75NTR in head and neck peripheral neural lesions. Reduction of BDNF and p75NTR in MPNST might suggest down-regulation during the acquisition of malignant phenotype
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COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
88887.31959/2019
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
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Immunoexpression of BDNF, TrkB, and p75NTR receptors in peripheral neural lesions of the head and neck
Julia Turra Ribeiro, Stéfanie Thieme, Paula Zettermann, Amanda Almeida Leite, Virgilio Gonzales Zanella, Emily Ferreira Salles Pilar, Felipe Paiva Fonseca, Ricardo Alves Mesquita, Pablo Agustin Vargas, Jean Nunes Santos, Manoela Domingues Martins
Immunoexpression of BDNF, TrkB, and p75NTR receptors in peripheral neural lesions of the head and neck
Julia Turra Ribeiro, Stéfanie Thieme, Paula Zettermann, Amanda Almeida Leite, Virgilio Gonzales Zanella, Emily Ferreira Salles Pilar, Felipe Paiva Fonseca, Ricardo Alves Mesquita, Pablo Agustin Vargas, Jean Nunes Santos, Manoela Domingues Martins
Fontes
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Journal of oral pathology and medicine Vol. 50, n. 5 (May, 2021), p. 492-501 |