Smoking and cardiac structure and function in the elderly : the ARIC study (atherosclerosis risk in communities)
Wilson Nadruz Jr, Brian Claggett, Alexandra Gonçalves, Gabriela Querejeta-Roca, Miguel M. Fernandes-Silva, Amil M. Shah, Susan Cheng, Hirofumi Tanaka, Gerardo Heiss, Dalane W. Kitzman, Scott D. Solomon
ARTIGO
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Agradecimentos: We thank the staff and participants of the ARIC study for their important contributions. The ARIC study is performed as a collaborative study supported by National Heart, Lung, and Blood Institute (NHLBI) contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100 007C,...
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Agradecimentos: We thank the staff and participants of the ARIC study for their important contributions. The ARIC study is performed as a collaborative study supported by National Heart, Lung, and Blood Institute (NHLBI) contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100 007C, HHSN268201100008C, HHSN268201100009C, HHSN 268201100010C, HHSN268201100011C, and HHSN268201100 012C). This work was also supported by NHLBI cooperative agreement NHLBI-HC-11-08 (Dr Solomon), grants R00-HL-107642 (Dr Cheng) and K08-HL-116792 (Dr Shah), and a grant from the Ellison Foundation (Dr Cheng). Dr Gonçalves was supported by the Portuguese Foundation for Science and Technology Grant HMSPICS/007/2012. Dr Nadruz was supported by the Brazilian National Council for Scientific and Technological Development Grant 249481/2013-8
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Abstract: Cigarette smoking has been associated with higher risk of incident heart failure independent of coronary artery disease, but the impact of tobacco use on cardiac structure and function in the general population is uncertain. This study evaluated the relationship between smoking and...
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Abstract: Cigarette smoking has been associated with higher risk of incident heart failure independent of coronary artery disease, but the impact of tobacco use on cardiac structure and function in the general population is uncertain. This study evaluated the relationship between smoking and echocardiographic measures in a large elderly cohort. We studied 4580 participants free of overt coronary artery disease, heart failure, and significant valvular disease from the fifth visit of the ARIC study (Atherosclerosis Risk in Communities) who underwent transthoracic echocardiography. Participants were classified into 3 categories based on self-reported smoking habits: never (43.2%), former (50.5%), and current smokers (6.3%). Pack-years and years of smoking were also estimated. Compared with never smokers, current smokers had greater left ventricular (LV) mass index (80.4±1.1 versus 76.7±0.4 g/m2; P<0.001), LV mass/volume ratio (1.93±0.03 versus 1.83±0.03 g/mL; P<0.001), higher prevalence of LV hypertrophy (15% versus 9%; P=0.008), and worse diastolic function, as reflected by higher E/E' ratio (11.7±0.2 versus 10.9±0.1; P<0.001), after adjusting for potential confounding factors. In contrast, former smokers showed similar echocardiographic features when compared with never smokers. Furthermore, estimated pack-years and years of smoking, measures of cumulative cigarette exposure, were associated with greater LV mass index, LV mass/volume ratio, and worse diastolic function (higher E/E' ratio) in current smokers after multivariable analysis (all P<0.01). Active smoking and cumulative cigarette exposure were associated with subtle alterations in LV structure and function in an elderly, community-based population free of overt coronary artery disease and heart failure
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
249481/2013-8
Fechado
Smoking and cardiac structure and function in the elderly : the ARIC study (atherosclerosis risk in communities)
Wilson Nadruz Jr, Brian Claggett, Alexandra Gonçalves, Gabriela Querejeta-Roca, Miguel M. Fernandes-Silva, Amil M. Shah, Susan Cheng, Hirofumi Tanaka, Gerardo Heiss, Dalane W. Kitzman, Scott D. Solomon
Smoking and cardiac structure and function in the elderly : the ARIC study (atherosclerosis risk in communities)
Wilson Nadruz Jr, Brian Claggett, Alexandra Gonçalves, Gabriela Querejeta-Roca, Miguel M. Fernandes-Silva, Amil M. Shah, Susan Cheng, Hirofumi Tanaka, Gerardo Heiss, Dalane W. Kitzman, Scott D. Solomon
Fontes
Circulation: cardiovascular imaging (Fonte avulsa) |