Osteonecrosis of the mandible associated with bevacizumab therapy
Alan Roger Santos-Silva, Giuliano Augusto Belizário Rosa, Gilberto de Castro Júnior, Reinaldo Brito Dias, Ana Carolina Prado Ribeiro, Thaís Bianca Brandão
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Bevacizumab is a humanized antibody that blocks vascular endothelial growth factor and is of great value for the treatment of advanced cancer. Several adverse effects following its administration have been reported. To date, only 8 cases of osteonecrosis of the...
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Bevacizumab is a humanized antibody that blocks vascular endothelial growth factor and is of great value for the treatment of advanced cancer. Several adverse effects following its administration have been reported. To date, only 8 cases of osteonecrosis of the jaws associatedwith bevacizumab (without any association with bisphosphonates) have been reported. The aim of this article was to describe an original case of bevacizumab-related osteonecrosis of the jaw. A 61-year-old man diagnosed with advanced renal cell carcinoma was undergoing treatment with intravenous bevacizumab and temsirolimus when he spontaneously developed mandible osteonecrosis, which resolved after 3 months of conservative management. The present case reinforces recent speculation that the anti-angiogenic properties of bevacizumabmay represent a potential new source of osteonecrosis of the jaws in patients undergoing cancer treatment. Multidisciplinary teams in cancer care should be aware of the possible association between osteonecrosis of the jaw and bevacizumab therapy
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Osteonecrosis of the mandible associated with bevacizumab therapy
Alan Roger Santos-Silva, Giuliano Augusto Belizário Rosa, Gilberto de Castro Júnior, Reinaldo Brito Dias, Ana Carolina Prado Ribeiro, Thaís Bianca Brandão
Osteonecrosis of the mandible associated with bevacizumab therapy
Alan Roger Santos-Silva, Giuliano Augusto Belizário Rosa, Gilberto de Castro Júnior, Reinaldo Brito Dias, Ana Carolina Prado Ribeiro, Thaís Bianca Brandão
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Oral surgery, oral medicine, oral pathology and oral radiology Vol. 115, no. 6 (June, 2013), p. e32-e36 |