Drug polarity effect over the controlled release in casein and chondroitin sulfate-based hydrogels
Andressa Renatta Simão, Vanessa H. Fragal, Michelly Cristina Galdioli Pellá, Francielle P. Garcia, Celso V. Nakamura, Rafael Silva, Elias B. Tambourgi, Adley F. Rubira
ARTIGO
Inglês
This study compared the controlled release of two drugs: vitamin-B12, and l-dopa from hydrogels based on 50% of casein (CAS, a protein), 50% of chondroitin sulfate (CS, a polysaccharide) and different amounts of SiO2. The results indicated that the incorporation of 5% of SiO2 to the materials,...
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This study compared the controlled release of two drugs: vitamin-B12, and l-dopa from hydrogels based on 50% of casein (CAS, a protein), 50% of chondroitin sulfate (CS, a polysaccharide) and different amounts of SiO2. The results indicated that the incorporation of 5% of SiO2 to the materials, allowed the best organization, distribution, and diameter of the pores, which are responsible for ensuring a more controlled release. Also, the matrices were not efficient in releasing vitamin-B12, but it successfully released l-dopa. It happened because vitamin-B12 is highly hydrophilic, interacting more with the medium than with the CAS/CS matrix, while l-dopa is less polar than vitamin-B12, interacting more with the CAS/CS matrix. It is worth mentioning that all synthesized hydrogels were non-toxic to the cells as showed by the in vitro assay. This work also demonstrated the importance of evaluating drug delivery devices using drugs of different polarities before stating if they are efficient or not
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COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
FINANCIADORA DE ESTUDOS E PROJETOS - FINEP
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
Fechado
Drug polarity effect over the controlled release in casein and chondroitin sulfate-based hydrogels
Andressa Renatta Simão, Vanessa H. Fragal, Michelly Cristina Galdioli Pellá, Francielle P. Garcia, Celso V. Nakamura, Rafael Silva, Elias B. Tambourgi, Adley F. Rubira
Drug polarity effect over the controlled release in casein and chondroitin sulfate-based hydrogels
Andressa Renatta Simão, Vanessa H. Fragal, Michelly Cristina Galdioli Pellá, Francielle P. Garcia, Celso V. Nakamura, Rafael Silva, Elias B. Tambourgi, Adley F. Rubira
Fontes
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International journal of biological macromolecules Vol. 158 (Sep., 2020), p. 116-126 |