Agradecimentos: The authors are grateful to CNPq (303525/2016-9, 305680/2015-3, 301486/2016-6, and 401689/2015-8), INCT-Bioanalítica (465389/2014-7), FAPEMA (Universal 00927/2016 and PRONEM 210383/2016), and FAPESP (2014/02163-7) for financial support. AGSN, CSS, and SMS are scholarship students...

Agradecimentos: The authors are grateful to CNPq (303525/2016-9, 305680/2015-3, 301486/2016-6, and 401689/2015-8), INCT-Bioanalítica (465389/2014-7), FAPEMA (Universal 00927/2016 and PRONEM 210383/2016), and FAPESP (2014/02163-7) for financial support. AGSN, CSS, and SMS are scholarship students from CNPq, Conselho Nacional de Desenvolvimento Científico e Tecnológico

Imipramine (IMP), a tricyclic antidepressant drug, is commonly prescribed for treatment of psychiatric patients suffering from different forms of depression. The appropriate amount of drug intake is crucial to ensure the optimum therapeutic effects minimizing severe collateral effects and toxicity....

Imipramine (IMP), a tricyclic antidepressant drug, is commonly prescribed for treatment of psychiatric patients suffering from different forms of depression. The appropriate amount of drug intake is crucial to ensure the optimum therapeutic effects minimizing severe collateral effects and toxicity. Therefore, the monitoring of imipramine is essential for its clinical applications. Herein, we report an electrochemical sensor based on a composite of ferrocenecarboxylic acid (FCA), beta-cyclodextrin (CD), and oxidized multi-walled carbon nanotubes (f-CNT) modified glassy carbon electrode for detection of IMP at low potential. The electrochemical behavior of the proposed sensor was characterized by scanning electron microscopy, Raman spectroscopy, and cyclic voltammetry. The results show that imipramine determination using the proposed sensor occurs around 0 V vs Ag/AgCl in phosphate buffer pH 7.0. The calibration curves were obtained by cyclic voltammetry and differential pulse voltammetry, with linear ranges of 10 to 350 mu mol L-1 and 0.1 to 10 mu mol L-1, respectively. A detection limit of 0.03 mu mol L-1 was obtained for the detection of IMP. The sensor was applied for IMP determination in psychotropic drugs and urine samples and the results show a recovery percentage between 99 and 101% for the analyte

FUNDAÇÃO DE AMPARO À PESQUISA E AO DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO DO MARANHÃO - FAPEMA

303525/2016-9; 305680/2015-3; 301486/2016-6; 401689/2015-8

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2014/02163-7

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

00927/2016; 210383/2016

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