Effects of morin on snake venom phospholipase A(2) (PLA(2))
R. Aparicio, H.S.A. Monteiro, L. Rodrigues-Simioni, L.O.S. Beriam, E.A. Camargo, E. Antunes, D.D. Toyoma, S. Marangoni, M.H. Toyama, C.V. Iglesias
ARTIGO
Inglês
Flavonoids are potent anti-inflammatory compounds isolated from several plant extracts, and have been used experimentally against inflammatory processes. In this work, a PLA(2) isolated from the Crotalus durissus cascavella venom and rat paw oedema were used as a model to. study the effect of...
Ver mais
Flavonoids are potent anti-inflammatory compounds isolated from several plant extracts, and have been used experimentally against inflammatory processes. In this work, a PLA(2) isolated from the Crotalus durissus cascavella venom and rat paw oedema were used as a model to. study the effect of flavonoids on PLA(2). We observed that a treatment of PLA(2) with morin induces several modifications in the aromatic amino acids, with accompanying changes in its amino acid composition. In addition, results from circular dichroism spectroscopy and UV scanning revealed important structural modifications. Concomitantly, a considerable decrease in the enzymatic and antibacterial activities was observed, even though anti-inflammatory and neurotoxic activities were not affected. These apparent controversial results may be an indication that PLA(2) possess a second pharmacological site which does not affect or depend on the enzymatic activity
Ver menos
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
04/00040-3
fechado
Effects of morin on snake venom phospholipase A(2) (PLA(2))
R. Aparicio, H.S.A. Monteiro, L. Rodrigues-Simioni, L.O.S. Beriam, E.A. Camargo, E. Antunes, D.D. Toyoma, S. Marangoni, M.H. Toyama, C.V. Iglesias
Effects of morin on snake venom phospholipase A(2) (PLA(2))
R. Aparicio, H.S.A. Monteiro, L. Rodrigues-Simioni, L.O.S. Beriam, E.A. Camargo, E. Antunes, D.D. Toyoma, S. Marangoni, M.H. Toyama, C.V. Iglesias
Fontes
|
Toxicon: an interdisciplinary journal on the toxins derived from animals, plants and microorganisms Vol. 46, no. 7 (Dec., 2005), p. 751-758 |