Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies
Yannick Tholance, Christian Peter Moritz, Carole Rosier, Karine Ferraud, Francois Lassabliere, Evelyne Reynaud-Federspiel, Marcondes C. Franca Jr., Alberto R. M. Martinez, Jean-Philippe Camdessanche, Jean-Christophe Antoine, David Adams, Cecile Cauquil, Shahram Attarian, Emilien Delmont, Genevieve...
Yannick Tholance, Christian Peter Moritz, Carole Rosier, Karine Ferraud, Francois Lassabliere, Evelyne Reynaud-Federspiel, Marcondes C. Franca Jr., Alberto R. M. Martinez, Jean-Philippe Camdessanche, Jean-Christophe Antoine, David Adams, Cecile Cauquil, Shahram Attarian, Emilien Delmont, Genevieve Blanchet-Fourcade, Celine Callias, Julien Cassereau, Ariane Choumert, Pierre Clavelou, Alain Creange, Gabriella Di Virgilio, Andoni Echaniz-Laguna, Benoit Faucher, Ian Galea, Steeve Genestet, Antoine Gueguen, Ioana M. Ion, Raul Juntas-Morales, Guillaume Taieb, Thierry Kuntzer, Emmeline Lagrange, Jean-Marc Leger, Tanya Stojkovic, Maud Lepetit, Laurent Magy, Julie Mas, Maud Michaud, Capucine Mouthon-Reignier, Jean-Philippe Neau, Canan Ozsancak, Yann Pereon, Paul Perrotte, Angela Puma, Yusuf A. Rajabally, Simon Rinaldi, Violaine Rouaud, Guilhem Sole, Celine Tard, Anne-Evelyne Vallet, Christophe Vial
ARTIGO
Inglês
Agradecimentos: This study was supported by University hospital of Saint-Etienne (NCT02539329). CPM was funded by the German Research Foundation (DFG; MO 3240/1-1:1) during the study. MCFJ has a research grant on SNN funded by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP,...
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Agradecimentos: This study was supported by University hospital of Saint-Etienne (NCT02539329). CPM was funded by the German Research Foundation (DFG; MO 3240/1-1:1) during the study. MCFJ has a research grant on SNN funded by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, 2013/01766-7). ARMM is supported by PhD scholarship from FAPESP (2013/26410-0)
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Sensory neuropathies (SNs) are often classified as idiopathic even if immunological mechanisms can be suspected. Antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly identify a subgroup of SN affecting mostly the dorsal root ganglion (DRG). The aim...
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Sensory neuropathies (SNs) are often classified as idiopathic even if immunological mechanisms can be suspected. Antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly identify a subgroup of SN affecting mostly the dorsal root ganglion (DRG). The aim of this study was to identify the frequency of anti-FGFR3 antibodies and the associated clinical pattern in a large cohort of patients with SN. A prospective, multicentric, European and Brazilian study included adults with pure SN. Serum anti-FGRF3 antibodies were analysed by ELISA. Detailed clinical and paraclinical data were collected for each anti-FGFR3-positive patient and as control for anti-FGFR3-negative patients from the same centres ('center-matched'). Sixty-five patients out of 426 (15%) had anti-FGFR3 antibodies, which were the only identified autoimmune markers in 43 patients (66%). The neuropathy was non-length dependent in 89% and classified as sensory neuronopathy in 64%, non-length-dependent small fibre neuropathy in 17% and other neuropathy in 19%. Specific clinical features occurred after 5-6 years of evolution including frequent paresthesia, predominant clinical and electrophysiological involvement of the lower limbs, and a less frequent mixed large and small fibre involvement. Brazilians had a higher frequency of anti-FGFR3 antibodies than Europeans (36% vs 13%, p<0.001), and a more frequent asymmetrical distribution of symptoms (OR 169, 95% CI 3.4 to 8424). Anti-FGFR3 antibodies occur in a subgroup of SN probably predominantly affecting the DRG. Differences between Europeans and Brazilians could suggest involvement of genetic or environmental factors
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2013/01766-7; 2013/26410-0
Fechado
DOI: https://doi.org/10.1136/jnnp-2019-321849
Texto completo: https://jnnp.bmj.com/content/91/1/49
Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies
Yannick Tholance, Christian Peter Moritz, Carole Rosier, Karine Ferraud, Francois Lassabliere, Evelyne Reynaud-Federspiel, Marcondes C. Franca Jr., Alberto R. M. Martinez, Jean-Philippe Camdessanche, Jean-Christophe Antoine, David Adams, Cecile Cauquil, Shahram Attarian, Emilien Delmont, Genevieve...
Yannick Tholance, Christian Peter Moritz, Carole Rosier, Karine Ferraud, Francois Lassabliere, Evelyne Reynaud-Federspiel, Marcondes C. Franca Jr., Alberto R. M. Martinez, Jean-Philippe Camdessanche, Jean-Christophe Antoine, David Adams, Cecile Cauquil, Shahram Attarian, Emilien Delmont, Genevieve Blanchet-Fourcade, Celine Callias, Julien Cassereau, Ariane Choumert, Pierre Clavelou, Alain Creange, Gabriella Di Virgilio, Andoni Echaniz-Laguna, Benoit Faucher, Ian Galea, Steeve Genestet, Antoine Gueguen, Ioana M. Ion, Raul Juntas-Morales, Guillaume Taieb, Thierry Kuntzer, Emmeline Lagrange, Jean-Marc Leger, Tanya Stojkovic, Maud Lepetit, Laurent Magy, Julie Mas, Maud Michaud, Capucine Mouthon-Reignier, Jean-Philippe Neau, Canan Ozsancak, Yann Pereon, Paul Perrotte, Angela Puma, Yusuf A. Rajabally, Simon Rinaldi, Violaine Rouaud, Guilhem Sole, Celine Tard, Anne-Evelyne Vallet, Christophe Vial
Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies
Yannick Tholance, Christian Peter Moritz, Carole Rosier, Karine Ferraud, Francois Lassabliere, Evelyne Reynaud-Federspiel, Marcondes C. Franca Jr., Alberto R. M. Martinez, Jean-Philippe Camdessanche, Jean-Christophe Antoine, David Adams, Cecile Cauquil, Shahram Attarian, Emilien Delmont, Genevieve...
Yannick Tholance, Christian Peter Moritz, Carole Rosier, Karine Ferraud, Francois Lassabliere, Evelyne Reynaud-Federspiel, Marcondes C. Franca Jr., Alberto R. M. Martinez, Jean-Philippe Camdessanche, Jean-Christophe Antoine, David Adams, Cecile Cauquil, Shahram Attarian, Emilien Delmont, Genevieve Blanchet-Fourcade, Celine Callias, Julien Cassereau, Ariane Choumert, Pierre Clavelou, Alain Creange, Gabriella Di Virgilio, Andoni Echaniz-Laguna, Benoit Faucher, Ian Galea, Steeve Genestet, Antoine Gueguen, Ioana M. Ion, Raul Juntas-Morales, Guillaume Taieb, Thierry Kuntzer, Emmeline Lagrange, Jean-Marc Leger, Tanya Stojkovic, Maud Lepetit, Laurent Magy, Julie Mas, Maud Michaud, Capucine Mouthon-Reignier, Jean-Philippe Neau, Canan Ozsancak, Yann Pereon, Paul Perrotte, Angela Puma, Yusuf A. Rajabally, Simon Rinaldi, Violaine Rouaud, Guilhem Sole, Celine Tard, Anne-Evelyne Vallet, Christophe Vial
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Journal of neurology, neurosurgery and psychiatry Vol. 91, no. 1 (Jan., 2019), p. 49-57 |