Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes
Sharon Nina Admoni, Daniele Pereira Santos-Bezerra, Ricardo Vesoni Perez, Thiago Andrade Patente, Maria Beatriz Monteiro, Ana Mercedes Cavaleiro, Maria Candida Parisi, Arnaldo Moura Neto, Elizabeth Joao Pavin, Marcia Silva Queiroz, Marcia Nery, Maria Lucia Correa-Giannella
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Agradecimentos: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) to D.P.S.-B. (12/25490-8) and to M.L.C.-G....
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Agradecimentos: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) to D.P.S.-B. (12/25490-8) and to M.L.C.-G. (09/09276-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) to S.N.A.; and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) to M.L.C.-G
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Cardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione peroxidase 4 is involved in the detoxification of peroxides and of reactive...
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Cardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione peroxidase 4 is involved in the detoxification of peroxides and of reactive oxygen species. Thus, the association of a functional variant in the gene encoding glutathione peroxidase 4 (rs713041) with this diabetic complication was investigated in 341 individuals with type 1 diabetes evaluated for cardiac autonomic neuropathy status (61.7% women, 34 [27–42] years old; diabetes duration: 21 [15–27] years; HbA1c: 8.3% [7.4–9.4]; as median [interquartile interval]). Cardiac autonomic neuropathy was present in 29% of the participants. There was an inverse association of the minor T allele of rs713041 with cardiac autonomic neuropathy (odds ratio=0.39; 95% confidence interval=0.17–0.90; p=0.0271) after adjustment for potential confounders. The functional glutathione peroxidase 4 variant rs713041 modulated the risk for cardiac autonomic neuropathy in the studied population with type 1 diabetes
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
12/25490-8; 09/09276-3
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Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes
Sharon Nina Admoni, Daniele Pereira Santos-Bezerra, Ricardo Vesoni Perez, Thiago Andrade Patente, Maria Beatriz Monteiro, Ana Mercedes Cavaleiro, Maria Candida Parisi, Arnaldo Moura Neto, Elizabeth Joao Pavin, Marcia Silva Queiroz, Marcia Nery, Maria Lucia Correa-Giannella
Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes
Sharon Nina Admoni, Daniele Pereira Santos-Bezerra, Ricardo Vesoni Perez, Thiago Andrade Patente, Maria Beatriz Monteiro, Ana Mercedes Cavaleiro, Maria Candida Parisi, Arnaldo Moura Neto, Elizabeth Joao Pavin, Marcia Silva Queiroz, Marcia Nery, Maria Lucia Correa-Giannella
Fontes
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Diabetes and vascular disease research Vol. 16, no. 3 (May., 2019), p. 297-299 |