Prevalence of HIV-1 transmitted drug resistance and viral suppression among recently diagnosed adults in Sao Paulo, Brazil
Luana Portes Ozorio Coelho, Elaine Monteiro Matsuda, Roberta Schiavon Nogueira, Monica Jacques de Moraes, Leda Fatima Jamal, Jose Valdez Ramalho Madruga, Mariza Vono Tancredi, Aline Carralas Queiroz de Leao, Giselle de Faria Romero Soldi, Luis Fernando de Macedo Brigido, Daniela Rodrigues Colpas,...
Luana Portes Ozorio Coelho, Elaine Monteiro Matsuda, Roberta Schiavon Nogueira, Monica Jacques de Moraes, Leda Fatima Jamal, Jose Valdez Ramalho Madruga, Mariza Vono Tancredi, Aline Carralas Queiroz de Leao, Giselle de Faria Romero Soldi, Luis Fernando de Macedo Brigido, Daniela Rodrigues Colpas, Gabriela Bastos Cabral, Giselle Ibete Silva Lopez Lopes, Norberto Camilo Campos, Isadora Coutinho Ribeiro, Cintia Mayumi Ahagon, Guilherme Penteado Teixeira, Joao Leandro de Paula Ferreira, Ivana Barros de Campos, Mariana Carvalho, Rafaella Gomes, Flavia Gennari Pinheiro, Jr. Pereira Luiz Carlos, Karen Morejon, Alvaro Furtado da Costa, Erika Maria do Nascimento Kalmar, Fabio Luis Nascimento Nogui, Patricia Rady Mueller, Silvia Pereira Goulart, Suzana Toledo da Silva Leme
ARTIGO
Inglês
HIV-1 transmitted drug resistance (TDR) mutations may reduce the efficacy of antiretroviral therapy (ART), but pre-treatment testing to determine the virus genotype can improve the efficacy of ART. Unfortunately, issues related to cost and logistics of pre-treatment testing limit its use in...
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HIV-1 transmitted drug resistance (TDR) mutations may reduce the efficacy of antiretroviral therapy (ART), but pre-treatment testing to determine the virus genotype can improve the efficacy of ART. Unfortunately, issues related to cost and logistics of pre-treatment testing limit its use in resource-limited settings. We studied 596 ART-naive individuals who were newly diagnosed from 2014 to 2016 in SAo Paulo, Brazil, to evaluate TDR and virological outcome after 48weeks of genotype-guided therapy. One or more TDR (based on the WHO surveillance list) was observed in 10.9% (CI 95%, 8.6-13.6) of the sequences, the most common of which was the K103N mutation, which confers resistance to first-generation drugs of the non-nucleoside reverse transcriptase inhibitor (NNRTI) antiretroviral drug class. Dual-class (1%, 6/596) and triple-class (0.34%, 2/596) resistance were uncommon. After 48weeks of treatment with ART, infection was suppressed to below 200 copies/mL in most patients (95%), with full suppression (RNA target not detected) in 65%. The following characteristics at patient enrollment were independently associated with a lack of full suppression: CD4 T cell counts below 500 cells/mu L, viremia above 100,000 copies/mL, older age, and TDR to NNRTI. The rates of resistance were intermediate, but genotype-guided therapy resulted in high rates of viral suppression. The observed resistance profile should not be an obstacle to the use of the dolutegravir-based regimen now recommended in Brazil, but genotype testing may be warranted before initiating first-generation NNRTI-based regimens
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2013/19441-7; 2016/14813-1
Fechado
Prevalence of HIV-1 transmitted drug resistance and viral suppression among recently diagnosed adults in Sao Paulo, Brazil
Luana Portes Ozorio Coelho, Elaine Monteiro Matsuda, Roberta Schiavon Nogueira, Monica Jacques de Moraes, Leda Fatima Jamal, Jose Valdez Ramalho Madruga, Mariza Vono Tancredi, Aline Carralas Queiroz de Leao, Giselle de Faria Romero Soldi, Luis Fernando de Macedo Brigido, Daniela Rodrigues Colpas,...
Luana Portes Ozorio Coelho, Elaine Monteiro Matsuda, Roberta Schiavon Nogueira, Monica Jacques de Moraes, Leda Fatima Jamal, Jose Valdez Ramalho Madruga, Mariza Vono Tancredi, Aline Carralas Queiroz de Leao, Giselle de Faria Romero Soldi, Luis Fernando de Macedo Brigido, Daniela Rodrigues Colpas, Gabriela Bastos Cabral, Giselle Ibete Silva Lopez Lopes, Norberto Camilo Campos, Isadora Coutinho Ribeiro, Cintia Mayumi Ahagon, Guilherme Penteado Teixeira, Joao Leandro de Paula Ferreira, Ivana Barros de Campos, Mariana Carvalho, Rafaella Gomes, Flavia Gennari Pinheiro, Jr. Pereira Luiz Carlos, Karen Morejon, Alvaro Furtado da Costa, Erika Maria do Nascimento Kalmar, Fabio Luis Nascimento Nogui, Patricia Rady Mueller, Silvia Pereira Goulart, Suzana Toledo da Silva Leme
Prevalence of HIV-1 transmitted drug resistance and viral suppression among recently diagnosed adults in Sao Paulo, Brazil
Luana Portes Ozorio Coelho, Elaine Monteiro Matsuda, Roberta Schiavon Nogueira, Monica Jacques de Moraes, Leda Fatima Jamal, Jose Valdez Ramalho Madruga, Mariza Vono Tancredi, Aline Carralas Queiroz de Leao, Giselle de Faria Romero Soldi, Luis Fernando de Macedo Brigido, Daniela Rodrigues Colpas,...
Luana Portes Ozorio Coelho, Elaine Monteiro Matsuda, Roberta Schiavon Nogueira, Monica Jacques de Moraes, Leda Fatima Jamal, Jose Valdez Ramalho Madruga, Mariza Vono Tancredi, Aline Carralas Queiroz de Leao, Giselle de Faria Romero Soldi, Luis Fernando de Macedo Brigido, Daniela Rodrigues Colpas, Gabriela Bastos Cabral, Giselle Ibete Silva Lopez Lopes, Norberto Camilo Campos, Isadora Coutinho Ribeiro, Cintia Mayumi Ahagon, Guilherme Penteado Teixeira, Joao Leandro de Paula Ferreira, Ivana Barros de Campos, Mariana Carvalho, Rafaella Gomes, Flavia Gennari Pinheiro, Jr. Pereira Luiz Carlos, Karen Morejon, Alvaro Furtado da Costa, Erika Maria do Nascimento Kalmar, Fabio Luis Nascimento Nogui, Patricia Rady Mueller, Silvia Pereira Goulart, Suzana Toledo da Silva Leme
Fontes
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Archives of virology: official journal of the virology division of the international union of microbiological societies Vol. 164, no. 3 (Mar., 2019), p. 699-706 |