Neonatal fluoxetine exposure modulates serotonergic neurotransmission and disturb inhibitory action of serotonin on food intake
Isabeli Lins Pinheiro, Aline Isabel da Silva, Andressa Reginato, Reginaldo Correia da Silva Filho, Ligia Cristina Monteiro Galindo, Rhowena Jane Barbosa Matos, Jose Candido de Souza Ferraz Junior, Ana Elisa Toscano Meneses da Silva Castro, Marciane Milanski Ferreira, Raul Manhaes de Castro, Sandra...
Isabeli Lins Pinheiro, Aline Isabel da Silva, Andressa Reginato, Reginaldo Correia da Silva Filho, Ligia Cristina Monteiro Galindo, Rhowena Jane Barbosa Matos, Jose Candido de Souza Ferraz Junior, Ana Elisa Toscano Meneses da Silva Castro, Marciane Milanski Ferreira, Raul Manhaes de Castro, Sandra Lopes de Souza
ARTIGO
Inglês
The neurotransmitter serotonin (5-HT) acts as an important regulator of the critical neurodevelopmental processes and thus alterations in 5-HT signaling early promotes permanent structural and functional changes in brain. The selective serotonin reuptake inhibitors (SSRIs), as fluoxetine and...
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The neurotransmitter serotonin (5-HT) acts as an important regulator of the critical neurodevelopmental processes and thus alterations in 5-HT signaling early promotes permanent structural and functional changes in brain. The selective serotonin reuptake inhibitors (SSRIs), as fluoxetine and citalopram, blocking serotonin transporter (SERT) at the presynaptic neuron, which regulates extracellular 5-HT levels. Evidence suggests that the exposure to SSRIs in the neurodevelopmental period may alters 5-HT signaling sensitivity on food intake control. The aim of the present study was to evaluate the effects of neonatal exposure to fluoxetine on molecular and cellular components of the serotonergic system and food intake control in young animals. Methods: The animals were divided according to experimental manipulation, Fluoxetine Group (FG): male pups received application of fluoxetine (10 mg/kg, 10 mu L/g) and Saline Group (SG): male pups received saline application (0.9% NaCl, 10 mu L/g), both throughout lactation (PND1-PND21). They evaluated body weight, food intake, SERT gene and protein expression, serotonin content in the hypothalamus. The neonatal exposure to fluoxetine promoted reduction in body weight, disturb the serotonin hypophagic response, and increase the serotonin and SERT hypothalamic in young animals. We conclude that the changes of components of the serotonergic system by neonatal exposure to fluoxetine may be responsible for disturb the inhibitory action of serotonin on food intake
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
Fechado
Neonatal fluoxetine exposure modulates serotonergic neurotransmission and disturb inhibitory action of serotonin on food intake
Isabeli Lins Pinheiro, Aline Isabel da Silva, Andressa Reginato, Reginaldo Correia da Silva Filho, Ligia Cristina Monteiro Galindo, Rhowena Jane Barbosa Matos, Jose Candido de Souza Ferraz Junior, Ana Elisa Toscano Meneses da Silva Castro, Marciane Milanski Ferreira, Raul Manhaes de Castro, Sandra...
Isabeli Lins Pinheiro, Aline Isabel da Silva, Andressa Reginato, Reginaldo Correia da Silva Filho, Ligia Cristina Monteiro Galindo, Rhowena Jane Barbosa Matos, Jose Candido de Souza Ferraz Junior, Ana Elisa Toscano Meneses da Silva Castro, Marciane Milanski Ferreira, Raul Manhaes de Castro, Sandra Lopes de Souza
Neonatal fluoxetine exposure modulates serotonergic neurotransmission and disturb inhibitory action of serotonin on food intake
Isabeli Lins Pinheiro, Aline Isabel da Silva, Andressa Reginato, Reginaldo Correia da Silva Filho, Ligia Cristina Monteiro Galindo, Rhowena Jane Barbosa Matos, Jose Candido de Souza Ferraz Junior, Ana Elisa Toscano Meneses da Silva Castro, Marciane Milanski Ferreira, Raul Manhaes de Castro, Sandra...
Isabeli Lins Pinheiro, Aline Isabel da Silva, Andressa Reginato, Reginaldo Correia da Silva Filho, Ligia Cristina Monteiro Galindo, Rhowena Jane Barbosa Matos, Jose Candido de Souza Ferraz Junior, Ana Elisa Toscano Meneses da Silva Castro, Marciane Milanski Ferreira, Raul Manhaes de Castro, Sandra Lopes de Souza
Fontes
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Behavioural Brain Research Vol. 357 (Jan., 2019), p. 65-70 |