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Type: Artigo de periódico
Title: Stereoselective Synthesis Of Conformationally Restricted Analogues Of Aspartic And Glutamic Acids Front Endocyclic Enecarbamates
Author: Carpes M.J.S.
Miranda P.C.M.L.
Correia C.R.D.
Abstract: The stereoselective synthesis of cyclic amino acids incorporating the care framework of aspartic acid and glutamic acids were accomplished from a common intermediate. Oxidative cleavage of an aza-bicyclic-dichlorocyclobutanone/pentanone with Me2CuLi/Ac2O followed by ozonolysis furnished the amino acid derivatives in good overall yields in a three-step sequence. This protocol was also applied to the synthesis of a cis-β-amino acid and to the enantioselective construction of a chimeric amino acid incorporating the basic skeleton of four different naturally occurring amino acids into a single structure.
Rights: fechado
Identifier DOI: 10.1016/S0040-4039(97)00238-4
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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