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|Type:||Artigo de periódico|
|Title:||Stereoselective Synthesis Of Conformationally Restricted Analogues Of Aspartic And Glutamic Acids Front Endocyclic Enecarbamates|
|Abstract:||The stereoselective synthesis of cyclic amino acids incorporating the care framework of aspartic acid and glutamic acids were accomplished from a common intermediate. Oxidative cleavage of an aza-bicyclic-dichlorocyclobutanone/pentanone with Me2CuLi/Ac2O followed by ozonolysis furnished the amino acid derivatives in good overall yields in a three-step sequence. This protocol was also applied to the synthesis of a cis-β-amino acid and to the enantioselective construction of a chimeric amino acid incorporating the basic skeleton of four different naturally occurring amino acids into a single structure.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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