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Type: Artigo de periódico
Title: Optimization Of A Process Of Continuous Enzyme Purification By Surface Response Analysis
Author: Rodrigues M.I.
Filho R.M.
Maugeri F.
Abstract: The methodology considered in this work for the optimization of an enzyme purification process by continuous adsorption recycle extraction (CARE) makes use of surface response analysis. The advantage of such approach is mainly concerned with the fact that it does not require the use of reduced models. In this way, through a detailed model of the system, it is possible to account for operational conditions, the whole set of process variables and design detail in the analysis. With this information, the main effects of each variable (among a group of seven) have been quantified, so that high yield can be achieved handling the enzyme feed concentration, the adsorption stage feed flow rate, the bed porosity and the recycling flow rate. For the productivity, beyond the enzyme feed concentration and the adsorption stage feed flow rate, the volumes of both adsorption and desorption are important. Through a two-star factorial procedure, it was possible to obtain mathematical relationships for the yield and productivity which are very useful in defining operating policy and design details in the search for optimal conditions. © 1993.
Rights: fechado
Identifier DOI: 10.1016/0956-7135(93)90301-4
Date Issue: 1993
Appears in Collections:Unicamp - Artigos e Outros Documentos

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