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Type: Artigo de periódico
Title: Modulation Of Polycation-induced Human Platelet Aggregation
Author: Marcondes S.
Grassi-Kassisse D.M.
Hyslop S.
De Nucci G.
Abstract: Polylysine-induced aggregation of human platelets was accompanied by thromboxane release and inhibited by iloprost and sodium nitroprusside. The aggregation of human platelets induced by polylysine paralleled its cationic content and was independent of the enantiomeric form of the polycation. ATP, indomethacin and the PAF antagonist WEB 2086 did not significantly affect polylysine-induced aggregation, although these agents did inhibit ADP-, collagen- and PAF-induced aggregation, respectively. Platelets stored for 24 h did not respond to adrenaline, ADP, collagen and PAF, but did aggregate to polylysine. This aggregation was indeed an aggregation since it was accompanied by TXB2 release and inhibited by iloprost and sodium nitroprusside. These results suggest that increases in cAMP and cGMP modulate expression of anionic sites on the platelet membrane.
Rights: fechado
Identifier DOI: 
Date Issue: 1993
Appears in Collections:Unicamp - Artigos e Outros Documentos

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