Please use this identifier to cite or link to this item:
|Type:||Artigo de periódico|
|Title:||Modulation Of Polycation-induced Human Platelet Aggregation|
De Nucci G.
|Abstract:||Polylysine-induced aggregation of human platelets was accompanied by thromboxane release and inhibited by iloprost and sodium nitroprusside. The aggregation of human platelets induced by polylysine paralleled its cationic content and was independent of the enantiomeric form of the polycation. ATP, indomethacin and the PAF antagonist WEB 2086 did not significantly affect polylysine-induced aggregation, although these agents did inhibit ADP-, collagen- and PAF-induced aggregation, respectively. Platelets stored for 24 h did not respond to adrenaline, ADP, collagen and PAF, but did aggregate to polylysine. This aggregation was indeed an aggregation since it was accompanied by TXB2 release and inhibited by iloprost and sodium nitroprusside. These results suggest that increases in cAMP and cGMP modulate expression of anionic sites on the platelet membrane.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.