Please use this identifier to cite or link to this item:
|Type:||Artigo de periódico|
|Title:||Effect Of Testosterone On The Response Of Young Rat Vas Deferens To Norepinephrine|
|Abstract:||1. 1. Following in vitro treatment with 12 μM 6-hydroxy-dopamine, 2 μM B-oestradiol, 0.1 μM propranolol and 10 μM cocaine vasa deferentia isolated from young rats (21-23 days old) showed supersensitivity to norepinephrine (NE) compared to those from adult (3 months old) rats. 2. 2. The pA2 values for prazosin were higher in young (9.6 ± 0.1) than in adult (8.3 ± 0.1) rat vas deferens, with the slopes of the Schild plots not different from 1.0 (0.78 ± 0.26 and 1.14 ± 0.14, respectively). 3. 3. The treatment of young rats with a single dose of testosterone abolished the supersensitivity to NE and the higher affinity for prazosin. 4. 4. We conclude that there is a reduction of neuronal NE uptake and a decrease in the sensitivity to NE in the vas deferens as the rat matures sexually. 5. 5. Testosterone induces a decrease in the sensitivity to NE, probably via an action on the α1-adrenoceptor population and the sympathetic nerve discharge in this organ. © 1993.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.