Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/99514
Type: Artigo de periódico
Title: Structure And Expression Of The Human Pseudoautosomal Gene Xe7
Author: Ellison J.W.
Ramos C.
Yen P.H.
Shapiro L.J.
Abstract: The human pseudoautosomal region comprises a 2.6 megabase segment of the distal short arms of the X and Y chromosomes. Complete DNA sequence homology between the two sex chromosomes is found in this region, and is believed to be important in mediating X-Y pairing in male meiosis. The only known functional genes in this region are M1C2 and CSF2R; in addition a pseudoautosomal location has been proposed for a genetic locus controlling stature. Here we report the structure of a recently identified pseudoautosomal gene, XE7, and its expression in human tissues. Analysis of genomic and cDNA clones shows that alternative RNA splicing results in the production of two predicted protein isoforms, one containing 385 amino acids and the other with 695 residues. The smaller polypeptide is a truncated version of the larger, and results from the inclusion of a cassette exon that introduces an in-frame stop codon into the mRNA. The XE7 gene appears to be ubiquitously expressed, and the production of both protein isoforms is predicted in each of several tissues examined.
Editor: 
Rights: fechado
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0027014298&partnerID=40&md5=51fd2ca5acfd1bb8371299bca8a3f12a
Date Issue: 1992
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.