Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/99470
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleMechanism Of Pain Induced By Radiocontrast Mediapt_BR
dc.contributor.authorCorrado A.P.pt_BR
dc.contributor.authorBallejo G.pt_BR
dc.contributor.authorAntunes E.pt_BR
dc.contributor.authorde Nucci G.pt_BR
unicamp.authorAntunes, E., Department of Pharmacology, Faculty of Medicine Sciences, UNICAMP, Campinas, SPBrazilpt_BR
unicamp.authorde Nucci, G., Department of Pharmacology, Faculty of Medicine Sciences, UNICAMP, Campinas, SPBrazilpt_BR
unicamp.author.externalCorrado, A.P., Department of Pharmacology, School of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão PretoBrazilpt
unicamp.author.externalBallejo, G., Department of Pharmacology, School of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão PretoBrazilpt
dc.description.abstractIn lightly-anesthetized dogs, ionic or non-ionic RCM (Iotalamato and iohexol, respectively) when injected by intracarotid route (i.e.), elicit a pain response comparable to that caused by bradykinin (BK) or capsaicin (CAP). This response, which is characterized by vocalization, hyperpnea, bradycardia and neck muscle contraction, was dose dependent and related to the osmolarity of the RCM. In the present study we observed that indomethacin did not interfere with CAP and RCM-induced pain at dose (2 mg/kg i.e.) that reduced BK-elicited responses. In contrast, Ruthenium Red (RR), in dose (1 mg/kg i.e.) that reduced CAP and/or RCM-induced effects did not affect BK-induced phenomena. We also verified that L-NAME (50 mg/kg i.e.) reduced the BK-, but not the CAP- and/or RCM-induced pain responses which suggests that an l-arginine-derived NO or related compound is involved in BK activation of perivascular nociceptors. Indeed, we found that i.e. injection of 20 mg of S-nitrosocysteine, a putative EDRF, caused BK-like responses. On the other hand, RCM and CAP appear to activate the same RR sensitive ionic channels of primary afferent endings. Therefore, RR-analogues could constitute a novel approach to minimizing or eventually abolishing the RCM side effects. © 1992.en
dc.relation.ispartofToxicology Letterspt_BR
dc.date.issued1992pt_BR
dc.identifier.citationToxicology Letters. , v. 64-65, n. C, p. 739 - 743, 1992.pt_BR
dc.language.isoenpt_BR
dc.description.volume64-65pt_BR
dc.description.issuenumberCpt_BR
dc.description.firstpage739pt_BR
dc.description.lastpage743pt_BR
dc.rightsfechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn3784274pt_BR
dc.identifier.doi10.1016/0378-4274(92)90255-Ipt_BR
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0026618859&partnerID=40&md5=024355802085ebb7d48e48f3d4285fc1pt_BR
dc.date.available2015-06-30T14:21:20Z
dc.date.available2015-11-26T14:43:03Z-
dc.date.accessioned2015-06-30T14:21:20Z
dc.date.accessioned2015-11-26T14:43:03Z-
dc.description.provenanceMade available in DSpace on 2015-06-30T14:21:20Z (GMT). No. of bitstreams: 1 2-s2.0-0026618859.pdf: 314320 bytes, checksum: 9a9335ec05e9211e5d7be8c19bbc7804 (MD5) Previous issue date: 1992en
dc.description.provenanceMade available in DSpace on 2015-11-26T14:43:03Z (GMT). No. of bitstreams: 1 2-s2.0-0026618859.pdf: 314320 bytes, checksum: 9a9335ec05e9211e5d7be8c19bbc7804 (MD5) Previous issue date: 1992en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/99470
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/99470-
dc.identifier.idScopus2-s2.0-0026618859pt_BR
dc.description.referenceVelaj, Drayer, Albright, Fram, Comparative neurotoxicity of angiographic contrast media (1985) Neurology, 35, pp. 1290-1295pt_BR
dc.description.referenceBetmann, Morris, Recent advances in contrast media (1986) Radiologic Clinics North America, 24, pp. 347-351pt_BR
dc.description.referenceSteinberg, Moore, Powe, Gopalan, Safety and cost effectiveness of high-osmolality as compared with low-osmolality contrast material in patients undergoing cardiac angiography (1992) New Engl. J. Med., 326, pp. 426-430pt_BR
dc.description.referenceBarrett, Parfrey, Vavasour, Ódea, A comparison of nonionic, low-osmolality radiocontrast agents with ionic, high-osmolality agents during cardiac catheterization (1992) New Engl. J. Med., 326, pp. 431-436pt_BR
dc.description.referenceCorrado, Ballejo, Is guanylate cyclase activation through the release of nitric oxide or a related compound involved in bradykinin-induced perivascular primary afferent excitation? (1992) Agents and Action Supplements, 36, pp. 238-250pt_BR
dc.description.referenceLasser, Talner, Santini, Lang, Pretreatment with corticosteroids to alleviate reactions to intravenous contrast material (1987) New Engl. J. Med., 317, pp. 845-850pt_BR
dc.description.referenceHock, Wirth, Linz, Gerhards, Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies (1991) Br. J. Pharmacol., 102, pp. 769-773pt_BR
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
2-s2.0-0026618859.pdf306.95 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.