Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/99408
Type: Artigo de periódico
Title: An Investigation Of The Electronic Structure Of The Antitumor Drug Ellipticine And Its Derivatives. Part I. Geometrical Am1 Study
Author: Dantas S.O.
Lavarda F.C.
Galvao D.S.
Laks B.
Abstract: Ellipticine and its derivatives are a class of molecules that show antitumor and cytotoxic activity with a multimodal mechanism of action. In this paper we report a preliminary Austin Method One (AM1) study of ellipticine and some molecules derived from it. We have observed a relationship between charge density distribution and biological selectivity. A mechanism that could improve cytotoxic activity is proposed. © 1992.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/0166-1280(92)87117-I
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0005515641&partnerID=40&md5=e5f33f29ec6fcdc4b50543ca5887ab18
Date Issue: 1992
Appears in Collections:Unicamp - Artigos e Outros Documentos

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