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|Type:||Artigo de periódico|
|Title:||An Investigation Of The Electronic Structure Of The Antitumor Drug Ellipticine And Its Derivatives. Part I. Geometrical Am1 Study|
|Abstract:||Ellipticine and its derivatives are a class of molecules that show antitumor and cytotoxic activity with a multimodal mechanism of action. In this paper we report a preliminary Austin Method One (AM1) study of ellipticine and some molecules derived from it. We have observed a relationship between charge density distribution and biological selectivity. A mechanism that could improve cytotoxic activity is proposed. © 1992.|
|Citation:||Journal Of Molecular Structure: Theochem. , v. 253, n. C, p. 319 - 332, 1992.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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