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Type: Artigo de periódico
Title: An Investigation Of The Electronic Structure Of The Antitumor Drug Ellipticine And Its Derivatives. Part I. Geometrical Am1 Study
Author: Dantas S.O.
Lavarda F.C.
Galvao D.S.
Laks B.
Abstract: Ellipticine and its derivatives are a class of molecules that show antitumor and cytotoxic activity with a multimodal mechanism of action. In this paper we report a preliminary Austin Method One (AM1) study of ellipticine and some molecules derived from it. We have observed a relationship between charge density distribution and biological selectivity. A mechanism that could improve cytotoxic activity is proposed. © 1992.
Citation: Journal Of Molecular Structure: Theochem. , v. 253, n. C, p. 319 - 332, 1992.
Rights: fechado
Identifier DOI: 10.1016/0166-1280(92)87117-I
Date Issue: 1992
Appears in Collections:Unicamp - Artigos e Outros Documentos

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