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Type: Artigo de periódico
Title: Insulin Secretion In Patients Deficient In Glucose-6-phosphate Dehydrogenase
Author: Monte Alegre S.
Saad S.T.O.
Delatre E.
Saad M.J.A.
Abstract: Intravenous (IVGTT) and oral glucose tolerance tests (OGTT) were carried out in 12 men with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and in 11 normal men. The race, the mean age and body mass index were similar in the G-6-PD deficient and in the normal men. No significant differences were demonstrated between mean plasma glucose levels in the G-6-PD deficient subjects and those in the normal men during IVGTT and OGTT. In contrast the insulin levels were significantly lower for the G-6-PD deficient subjects as compared to the controls at 30 minutes (P < 0.04) in the OGTT and at 1 min (P < 0.001), 3 min (P < 0.001), 5 min (P < 0.001) and 10 minutes (P < 0.002) in the IVGTT. All indexes of first phase insulin release were also significantly (P < 0.001) lower in G-6-PD deficient men. These results emphasize the metabolic importance of G-6-PD in the process of glucose induced insulin release.
Rights: aberto
Identifier DOI: 
Date Issue: 1991
Appears in Collections:Unicamp - Artigos e Outros Documentos

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