Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/99195
Type: Artigo de periódico
Title: Theophylline Therapy Inhibits Neutrophil And Mononuclear Cell Chemotaxis From Chronic Asthmatic Children
Author: Condino-Neto A.
Vilela M.M.S.
Cambiucci E.C.
Ribeiro J.D.
Guglielmi A.A.G.
Magna L.A.
De Nucci G.
Abstract: 1. Theophylline is commonly used to relieve symptoms of chronic asthma. Since neutrophil and mononuclear cell activation are associated with late phase asthmatic reactions, effects of theophylline on these cells may be of importance. 2. In the present investigation we compared neutrophil and mononuclear cell chemotaxis from chronic asthmatic children during and after theophylline therapy. 3. Thirty patients were recruited for the study. Each patient received theophylline orally for 10 days. The theophylline dose was 20 mg kg -1 day -1 given in four divided doses. On the tenth day, blood was collected into heparinized (100 u ml -1) and siliconized tubes 2 h after the last theophylline dose for chemotactic assays, cAMP and theophylline plasma determinations. When clinical conditions allowed, theophylline was discontinued for 7 days and the chemotactic assays, cAMP and theophylline plasma concentrations repeated. Serum complement and IgE levels were also determined. 4. Theophylline therapy clearly inhibited both spontaneous and stimulated neutrophil and mononuclear cell chemotaxis. Twenty-seven patients had therapeutic plasma concentrations of theophylline (5-20 μg ml -1). Discontinuation of theophylline therapy caused a significant decrease in plasma cAMP levels (44 and 31 pmol ml -1 respectively during and after treatment, n = 30, P < 0.001). 5. The inhibition of neutrophil and mononuclear cell migration by theophylline therapy in chronic asthmatic children may be beneficial for the control of the inflammatory response observed in these patients.
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Rights: fechado
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0026012430&partnerID=40&md5=76b223b7d6ac7626aaec9dcc233ef9b9
Date Issue: 1991
Appears in Collections:Unicamp - Artigos e Outros Documentos

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