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Type: Artigo
Title: Insulin resistance in essential hypertension
Author: Gontijo, J.A.
Saad, M.J.
Muscelli, E.O.
Abstract: To determine the possible existence of a relationship between insulin resistance and sympathetic nervous system activity in essential hypertension, we calculated the double cross index for 14 hypertensive subjects and 14 normotensive subjects submitted to the oral glucose test. Plasma glucose and insulin levels were similar in hypertensive and normotensive subjects. After glucose loading, however, both parameters were significantly higher in hypertensive subjects. Five out of 14 hypertensive patients were hyperinsulinemic. The increase in double cross index following a glucose load was significantly higher in normotensive volunteers than in hyperinsulinemic hypertensive subjects. No change in double cross index was observed in normoinsulinemic hypertensive subjects. Thus, insulin resistance, high blood glucose level, impairment of cardiac response and hyperinsulinemia are present in a significant portion of hypertensive patients. Hyperinsulinemia may contribute to hypertension by stimulating sympathetic nervous system activity, by influencing the calcium transport across the cell membrane and/or by some other mechanism
Subject: Hipertensão
Country: Brasil
Editor: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal Of Medical And Biological Research. , v. 23, n. 12, p. 1253 - 1257, 1990.
Rights: fechado
Date Issue: 1990
Appears in Collections:FCM - Artigos e Outros Documentos

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