Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/98633
Type: Artigo de periódico
Title: Possible Participation Of Membrane Thiol Groups On The Mechanism Of Nad(p)+-stimulated Ca2+ Efflux From Mitochondria
Author: Vercesi A.E.
Abstract: NAD(P)+-stimulated Ca2+ efflux from mitochondria is inhibited by bongkrekate and slightly stimulated by carboxyatractylate. Addition of oxaloacetate, and NAD(P) oxidant, or diamide, a thiol oxidant, to de-energized mitochondria incubated in Ca2+-free medium induced a small decrease in turbidity of the mitochondrial suspension compatible with small structural changes of mitochondria. Similar to NADP+-stimulated Ca2+ efflux these changes were also inhibited by bongkrekate and slightly stimulated by carboxyatractylate. The similarity between the effects of oxaloacetate and diamide, on both Ca2+ efflux and mitochondrial structure, indicates the existence of a common denominator, possibly the oxidation of specific thiol groups, regarding the mechanism by which these agents stimulate Ca2+ efflux from mitochondria. © 1984.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/0006-291X(84)91652-8
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0021772692&partnerID=40&md5=b36712937bfcb73fbc04ddd74cc2bc04
Date Issue: 1984
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
2-s2.0-0021772692.pdf341.82 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.