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Type: Artigo de periódico
Title: Possible Participation Of Membrane Thiol Groups On The Mechanism Of Nad(p)+-stimulated Ca2+ Efflux From Mitochondria
Author: Vercesi A.E.
Abstract: NAD(P)+-stimulated Ca2+ efflux from mitochondria is inhibited by bongkrekate and slightly stimulated by carboxyatractylate. Addition of oxaloacetate, and NAD(P) oxidant, or diamide, a thiol oxidant, to de-energized mitochondria incubated in Ca2+-free medium induced a small decrease in turbidity of the mitochondrial suspension compatible with small structural changes of mitochondria. Similar to NADP+-stimulated Ca2+ efflux these changes were also inhibited by bongkrekate and slightly stimulated by carboxyatractylate. The similarity between the effects of oxaloacetate and diamide, on both Ca2+ efflux and mitochondrial structure, indicates the existence of a common denominator, possibly the oxidation of specific thiol groups, regarding the mechanism by which these agents stimulate Ca2+ efflux from mitochondria. © 1984.
Rights: fechado
Identifier DOI: 10.1016/0006-291X(84)91652-8
Date Issue: 1984
Appears in Collections:Unicamp - Artigos e Outros Documentos

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