Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/98517
Type: Artigo de periódico
Title: Dissociation Of The Toxic And Behavioral Effects Of Lithium On Rats
Author: Teixeira N.A.
Karniol I.G.
Abstract: In a previous study we have shown that weight loss or animal death as a sign of toxicity due to the chronic administration of lithium in rats is more intense among male than female adult animals (5 months old), and is not observed in growing male and female animals (2 months old). In this study we report the results obtained for the same animals in the open field test. The ip administration of 3.0 mEq/day of LiCl to female rats for 28 days produced a decrease in rearing (60- and 150-day old animals) and ambulation (150-day old animals) in relation to control animals. Male rats of both ages submitted to the same treatment showed no changes in rearing or ambulation. The low level of activity observed in the male control groups during the 2nd and 4th experimental week may probably explain the lack of lithium effect on the number of rearing (both age groups) and ambulation (older animals) activities. We conclude that, under the present experimental conditions, the behavioral effects of lithium on female rats are dissociated from the toxic action of this substance.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0022375976&partnerID=40&md5=08b8d17e9adfb8cbe472dbfc5d9bbcc2
Date Issue: 1985
Appears in Collections:Unicamp - Artigos e Outros Documentos

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