Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/98516
Type: Artigo de periódico
Title: Muscular Lesions Induced By A Hemorrhagic Factor From Bothrops Neuwiedi Snake Venom
Author: Queiroz L.S.
Santo Neto H.
Assakura M.T.
Reichl A.P.
Mandelbaum F.R.
Abstract: The local tissue effects of crude Bothrops neuwiedi snake venom and of its hemorrhagic factor (NHF) were studied on mouse tibialis anterior muscle in vivo. After 6 h, 8 days and 6 weeks the muscles were examined in paraffin sections stained with hematoxylin and eosin. Both NHF and crude venom produced hemorrhage and myonecrosis, later followed by muscle fiber regeneration. Intramuscular arteries also suffered necrosis. The minimal dose of NHF necessary to produce detectable hemorrhage and myonecrosis was 50 ng, while the minimal venom dose needed to produce the same effect was 20 times higher. The results indicate that NHF is one of the major factors responsible for the local effects of B. neuwiedi venom.
Editor: 
Rights: aberto
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0022375876&partnerID=40&md5=2f4414eb9f4e4adf5b6cd2ea8de25a66
Date Issue: 1985
Appears in Collections:Unicamp - Artigos e Outros Documentos

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