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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePathological Changes In Muscle Caused By Haemorrhagic And Proteolytic Factors From Bothrops Jararaca Snake Venompt_BR
dc.contributor.authorQueiroz L.S.pt_BR
dc.contributor.authorSanto Neto H.pt_BR
dc.contributor.authorAssakura M.T.pt_BR
dc.contributor.authorReichl A.P.pt_BR
dc.contributor.authorMandelbaum F.R.pt_BR
unicamp.authorQueiroz, L.S., Department of Pathology State University of Campinas (UNICAMP), Caixa Postal 6111, 13100 Campinas, SP, Brazilpt_BR
unicamp.authorSanto Neto, H., Department of Anatomy, State University of Campinas (UNICAMP), Caixa Postal 6111, 13100 Campinas, SP, Brazilpt_BR
unicamp.author.externalAssakura, M.T., Department of Biochemistry, Instituto Butantan, Caixa Postal 65, 05504 São Paulo, SP, Brazilpt
unicamp.author.externalReichl, A.P., Department of Biochemistry, Instituto Butantan, Caixa Postal 65, 05504 São Paulo, SP, Brazilpt
unicamp.author.externalMandelbaum, F.R., Department of Biochemistry, Instituto Butantan, Caixa Postal 65, 05504 São Paulo, SP, Brazilpt
dc.description.abstractHaemorrhagic factor HF2 and bothropasin, two metalloproteins isolated from the venom of Bothrops jararaca, caused haemorrhage followed by myonecrosis and arterial necrosis after i.m. injection in mice. The effects of HF2 were qualitatively similar to those of bothropasin and crude B. jararaca venom, but its potency was about 20 times higher. The haemorrhagic and necrotizing actions of these components are unrelated to their proteolytic activity on casein. © 1985.en
dc.relation.ispartofToxiconpt_BR
dc.date.issued1985pt_BR
dc.identifier.citationToxicon. , v. 23, n. 2, p. 341 - 345, 1985.pt_BR
dc.language.isoenpt_BR
dc.description.volume23pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage341pt_BR
dc.description.lastpage345pt_BR
dc.rightsfechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn410101pt_BR
dc.identifier.doi10.1016/0041-0101(85)90158-8pt_BR
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0021833309&partnerID=40&md5=b0b6f023566e8c87f6dc4ea86aff65e5pt_BR
dc.description.sponsorshipNSERC; Natural Sciences and Engineering Research Council of Canadapt_BR
dc.date.available2015-06-30T13:42:25Z
dc.date.available2015-11-26T14:37:52Z-
dc.date.accessioned2015-06-30T13:42:25Z
dc.date.accessioned2015-11-26T14:37:52Z-
dc.description.provenanceMade available in DSpace on 2015-06-30T13:42:25Z (GMT). No. of bitstreams: 1 2-s2.0-0021833309.pdf: 523268 bytes, checksum: f766ffd98afa60b8de594fe04681356f (MD5) Previous issue date: 1985en
dc.description.provenanceMade available in DSpace on 2015-11-26T14:37:52Z (GMT). No. of bitstreams: 1 2-s2.0-0021833309.pdf: 523268 bytes, checksum: f766ffd98afa60b8de594fe04681356f (MD5) Previous issue date: 1985en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/98473
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/98473-
dc.identifier.idScopus2-s2.0-0021833309pt_BR
dc.description.referenceBrazil, (1914) La Défense Contre l'Ophidisme, , 2nd Edn., Pocai & Weiss, São Paulopt_BR
dc.description.referenceHoussay, Acción local de los venenos de serpientes (1923) Revta Asoc. méd. Argent., 36, p. 39pt_BR
dc.description.referencede Lacerda, (1881) Provas Experimentaes de que a Peçonha das Cobras é um Succo Digestivo, , Museu Nacional, Rio de Janeiropt_BR
dc.description.referenceMandelbaum, Reichl, Assakura, Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca (1976) Animal, Plant and Microbial Toxins, 1, p. 111. , A. Ohsaka, K. Hayashi, Y. Saway, Plenum Press, Londonpt_BR
dc.description.referenceMandelbaum, Reichl, Assakura, Isolation and characterization of a proteolytic enzyme from the venom of the snake Bothrops jararaca (jararaca) (1982) Toxicon, 20, p. 955pt_BR
dc.description.referenceOwnby, Bjarnason, Tu, Hemorrhagic toxins from rattlesnake (Crotalus atrox) venom (1978) Pathogenesis of hemorrhage induced by three purified toxins, 93, p. 201. , Am. J. Pathpt_BR
dc.description.referenceQueiroz, Santo Neto, Rodrigues-Simioni, Prado-Franceschi, Muscle necrosis and regeneration after envenomation by Bothrops jararacussu snake venom (1984) Toxicon, 22, p. 339pt_BR
dc.description.referenceQueiroz, Santo Neto, Brandeburgo, Simioni, Giglio, Histopathological changes caused by a myotoxin from Bothrops jararacussu snake venom (1985) Comparison with the effects of whole venom. Abstract, 23, p. 17. , Toxiconpt_BR
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