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Type: Artigo de periódico
Title: Interaction Of Phenytoin And Inflammationn Induces Gingival Overgrowth In Rats
Author: Do Nascimento A.
De Castro Barreto R.
Bozzo L.
Abstract: In adult male Wistar rats (Rattus norvegicus albinus) gingival irritation provided by means of wire silk ligatures around the cervix of first left lower molars, for a duration of 77 days, caused gingival inflammatory changes. In the rats receiving also daily one i.p. injection of sodium 5,5-diphenylhydantoinate (phenytoin), during 70 days, there was no macroscopical change of the gingiva of non-ligated first right lower molars. However, in the first left lower molars, the association of silk ligature-plus-phenytoin administration elicited gingival overgrowth. The rat was seen as a satisfactory animal model for studies of phenytoin-induced gingival changes.
Rights: fechado
Identifier DOI: 
Date Issue: 1985
Appears in Collections:Unicamp - Artigos e Outros Documentos

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