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|Type:||Artigo de periódico|
|Title:||Interaction Of Phenytoin And Inflammationn Induces Gingival Overgrowth In Rats|
|Author:||Do Nascimento A.|
De Castro Barreto R.
|Abstract:||In adult male Wistar rats (Rattus norvegicus albinus) gingival irritation provided by means of wire silk ligatures around the cervix of first left lower molars, for a duration of 77 days, caused gingival inflammatory changes. In the rats receiving also daily one i.p. injection of sodium 5,5-diphenylhydantoinate (phenytoin), during 70 days, there was no macroscopical change of the gingiva of non-ligated first right lower molars. However, in the first left lower molars, the association of silk ligature-plus-phenytoin administration elicited gingival overgrowth. The rat was seen as a satisfactory animal model for studies of phenytoin-induced gingival changes.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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