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Type: Artigo de periódico
Title: Electron Transport In Biological Processes. Deoxyribonucleic Acid Degradation And Its Relationship With The Electrochemical Behaviour Of Hydroxyquinone Derivatives
Author: Schrebler R.
Araya R.
Arratia A.
Ciampi D.B.
Hoffmann M.E.
Duran N.
Abstract: 2,3,5,6-Tetrahydroxy-2,5-cyclohexadiene-1,4-dione (THCD) autooxidizes under physiological conditions with concomitant production of 5,6-dihydroxy-5-cyclohexane-1,2,3,4-tetrone (DHCT). The (-d[Quinone]/dt)/(d[O2 - ]/dt) ratio indicates mixed one- and two-electron transfer mechanisms. Utilizing a heme group adsorbed on a carbon electrode under anaerobic conditions at pH 6 as model for the respiratory chain, the current peak of the first stage was associated with a net transfer of two electrons and two protons. Experimental redox potentials (U1 2) and the theoretical ionization potential values were indicative that the lowest redox and ionization potentials exhibit higher biological reactivity. This reactivity was tested on DNA transformation. © 1987.
Rights: fechado
Identifier DOI: 10.1016/0302-4598(87)80060-0
Date Issue: 1987
Appears in Collections:Unicamp - Artigos e Outros Documentos

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