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Type: Artigo de periódico
Title: Ca2+-dependent Nad(p)+-induced Alterations Of Rat Liver And Hepatoma Mitochondrial Membrane Permeability
Author: Vercesi A.E.
Ferraz V.L.
Macedo D.V.
Fiskum G.
Abstract: Deenergized rat liver or AS-30D hepatoma mitochondria underwent extensive swelling when incubated in the presence of Ca2+ and an oxidant of mitochondrial pyridine nucleotides. This swelling was stimulated by phosphate and inhibited by ruthenium red, Mg2+ plus ATP and dibucaine. The degree of inhibition by dibucaine was shown to vary inversely with the Ca2+ concentration. The inhibition caused by ruthenium red was completely removed by the Ca2+ ionophore ionomycin indicating that the effect of the cation is mediated by internal binding sites. Since mitochondria were totally deenergized the data definitely rule out the requirement for Ca2+ cycling across the membrane in this mechanism. © 1988.
Rights: fechado
Identifier DOI: 10.1016/0006-291X(88)90229-X
Date Issue: 1988
Appears in Collections:Unicamp - Artigos e Outros Documentos

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