Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/98093
Type: Artigo de periódico
Title: Repeated Swimming Stress And Responsiveness Of The Isolated Rat Pacemaker To The Chronotropic Effect Of Noradrenaline And Isoprenaline: Role Of Adrenal Corticosteroids
Author: Spadari R.C.
De Moraes S.
Abstract: 1. 1. Repeated swimming stress (three daily sessions) resulted in an increased plasma corticosterone level and subsensitivity of the isolated rat pacemaker to noradrenaline and isoprenaline. 2. 2. Repeated swimming stress was found to decrease the affinity of β1-adrenoreceptors for metoprolol. 3. 3. Bilateral adrenalectomy performed 2 days before repeated swimming stress abolished the development of pacemaker subsensitivity to noradrenaline and isoprenaline and the decrease in β1-adrenoreceptors affinity for metoprolol. 4. 4. It is concluded that adrenal corticosteroids, at least partially, mediate the swimming stress-induced subsensitivity of the isolated rat pacemaker to noradrenaline and isoprenaline. © 1988.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/0306-3623(88)90163-2
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0023884858&partnerID=40&md5=87e8fcf6e14e5ffa950c5bc6c94e702d
Date Issue: 1988
Appears in Collections:Unicamp - Artigos e Outros Documentos

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