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Type: Artigo de periódico
Title: Bacterial Chemistry-iii: Preliminary Studies On Trypanosomal Activities Of Chromobacterium Violaceum Products.
Author: Duran N.
Campos V.
Riveros R.
Joyas A.
Pereira M.F.
Haun M.
Abstract: It has been found that the pigment-I from Chromobacterium violaceum, 3-[1,2-dihydro5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-yli diene] 1,3-dihydro-2H-indol-2-one, has trypanocide activity. The formylated derivatives, pigment-III, immobilized 100% of the Trypanosoma cruzi at a level of 46 microM after 48 h of interaction with a total growth inhibition in the same period. Pigment-I exhibited low toxicity and a DNA synthesis inhibition similar to that of Nifurtimox, a known trypanocide compound.
Rights: aberto
Identifier DOI: 
Date Issue: 1989
Appears in Collections:Unicamp - Artigos e Outros Documentos

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