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Type: Artigo de periódico
Title: Crystallinity Of Dynasan ®114 And Dynasan ®118 Matrices For The Production Of Stable Miglyol ®-loaded Nanoparticles
Author: Severino P.
Pinho S.C.
Souto E.B.
Santana M.H.A.
Abstract: This study focuses on the physicochemical characterization of lipid materials useful for the production of the so-called solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). The chosen lipids were Dynasan ®114 (glyceril trimyristate) and Dynasan ®118 (glyceril tristearate) as solid lipids (SL), melting temperature above 80 °C, and Miglyol ®812 (caprylic/capric triglyceride) and Miglyol ®840 (propylene glycol dicaprylate/dicaprate) as liquid lipids (LL), crystallizing below -15 °C. Raw lipids (pure or SL:LL mixtures) were analyzed by differential scanning calorimetry (DSC), wide angle X-ray diffraction (WAXD), and Polarized Light Microscopy (PLM), before and after tempering at 80 °C for 1 h. The selected SL:LL combination was 70% (Dynasan ®114 and 118) and 30% (Miglyol ®812 and 840) for the production of SLN and NLC by high-pressure homogenization (HPH), respectively. Particles with a mean size of 200 nm (polydispersity index <0.329) and zeta potential of -15 mV were obtained, and their long-term stability was confirmed for 3 months of storage at 7 °C. © 2011 Akadémiai Kiadó, Budapest, Hungary.
Rights: fechado
Identifier DOI: 10.1007/s10973-011-1613-7
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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