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Type: Artigo de periódico
Title: Physicochemical Study And Characterization Of The Trimethoprim/2- Hydroxypropyl-γ-cyclodextrin Inclusion Complex
Author: MacEdo O.F.L.
Andrade G.R.S.
Conegero L.S.
Barreto L.S.
Costa Jr. N.B.
Gimenez I.F.
Almeida L.E.
Kubota D.
Abstract: Here we report the preparation of a trimethoprim/2-hydroxypropyl-γ- cyclodextrin inclusion complex along with a physicochemical study, structural characterization, and molecular modeling of the complex. As main results, we observed from phase-solubility studies at two temperatures (20 °C and 35 °C) that the association constants decrease with increasing temperature. Values for K 1:1 constant were of the same magnitude order of those found for the parent γ-CD. The inclusion orientation as evidenced by ROESY measurements involves the inclusion of the 3,4,5-trimethoxybenzyl ring in the CD cavity from the larger rim. This is in agreement with semiempirical molecular modeling calculation. © 2011 Elsevier B.V. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.saa.2011.10.010
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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