Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/97399
Type: Artigo de periódico
Title: Physicochemical Study And Characterization Of The Trimethoprim/2- Hydroxypropyl-γ-cyclodextrin Inclusion Complex
Author: MacEdo O.F.L.
Andrade G.R.S.
Conegero L.S.
Barreto L.S.
Costa Jr. N.B.
Gimenez I.F.
Almeida L.E.
Kubota D.
Abstract: Here we report the preparation of a trimethoprim/2-hydroxypropyl-γ- cyclodextrin inclusion complex along with a physicochemical study, structural characterization, and molecular modeling of the complex. As main results, we observed from phase-solubility studies at two temperatures (20 °C and 35 °C) that the association constants decrease with increasing temperature. Values for K 1:1 constant were of the same magnitude order of those found for the parent γ-CD. The inclusion orientation as evidenced by ROESY measurements involves the inclusion of the 3,4,5-trimethoxybenzyl ring in the CD cavity from the larger rim. This is in agreement with semiempirical molecular modeling calculation. © 2011 Elsevier B.V. All rights reserved.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.saa.2011.10.010
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-83655184776&partnerID=40&md5=73dd3130765a7821e4ecd61ece80540a
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.