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Type: Artigo de periódico
Title: Serological Profiles And Evaluation Of Parasitaemia By Pcr And Blood Culture In Individuals Chronically Infected By Trypanosoma Cruzi Treated With Benzonidazole
Author: Aguiar C.
Batista A.M.
Pavan T.B.S.
Almeida E.A.
Guariento M.E.
Wanderley J.S.
Costa S.C.B.
Abstract: Objective To evaluate the serological and parasitological status of patients with chronic Chagas disease (CD) after chemotherapy with benzonidazole. Methods Retrospective study of patients treated with benzonidazole (5mg/kg/day for 60days) between 1980 and 2010. Twenty-nine patients who had CD confirmed by two reagent immunological tests and/or one positive xenodiagnosis before treatment were included. Conventional serology (ELISA and IIF) and parasitological tests (haemoculture and N-PCR) were performed. Results At the time of treatment, the mean age of patients was 36±7.24years (20-39years) and the time post-treatment varied from 1 to 29years. After chemotherapy, all individuals had reagent ELISA and 93.1% had positive results for the IIF test. T. cruzi DNA was detected by N-PCR in 48.3%. Negative results were observed in 41.4% and inconclusive ones in 10.3%. Haemoculture was negative for all individuals. Conclusions Our results suggest that N-PCR may be useful in the early identification of therapeutic failure of CD. Although it is difficult to determine parasitological cure in negative N-PCR cases, we can infer that this condition represents a declination of parasitaemia as a favourable consequence of aetiological treatment. © 2011 Blackwell Publishing Ltd.
Rights: fechado
Identifier DOI: 10.1111/j.1365-3156.2011.02936.x
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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