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Type: Artigo de periódico
Title: A Ph/enzyme-responsive Polymer Film Consisting Of Eudragit® Fs 30 D And Arabinoxylane As A Potential Material Formulation For Colon-specific Drug Delivery System
Author: Rabito M.F.
Reis A.V.
Reis Freitas A.D.
Tambourgi E.B.
Cavalcanti O.A.
Abstract: Polymer film based on pH-dependent Eudragit® FS 30 D acrylic polymer in association with arabinoxylane, a polysaccharide issued from gum psyllium, was produced by way of solvent casting. Physical-chemical characterization of the polymer film samples was performed by means of thermogravimetry (TGA), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). Furthermore, water-equilibrium swelling index (Is) and weight loss of the films in KCl buffer solution of pH 1.2, in KH 2PO 4 buffer solution of pH 5.0, or in KH 2PO 4 buffer solution of pH 5.0 consisting of 4% enzyme Pectinex® 3X-L (w/v) were also carried out for the film characterization. No chemical interactions between the Eudragit® FS 30 D and the arabinoxylane polymer chains were evidenced, thus suggesting that the film-forming polymer structure was obtained from a physical mixture of both polymers. The arabinoxylane-loader films showed a more pronounced weight loss after their immersion in buffer solution containing enzyme Pectinex® 3X-L. The introduction of the arabinoxylane makes the film more susceptible to undergo an enzymatic degradation. This meant that the enzyme-dependent propriety issued from the arabinoxylane has been imprinted into the film formulation. This type of polymer film is an interesting system for applications in colon-specific drug delivery system. © 2012 Informa Healthcare USA, Inc.
Rights: fechado
Identifier DOI: 10.3109/10837450.2010.546409
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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