Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/97272
Type: Artigo de periódico
Title: Synthesis Of Methoxylated Goniothalamin, Aza-goniothalamin And γ-pyrones And Their In Vitro Evaluation Against Human Cancer Cells
Author: Barcelos R.C.
Pastre J.C.
Caixeta V.
Vendramini-Costa D.B.
De Carvalho J.E.
Pilli R.A.
Abstract: The present work describes the preparation of three novel series of compounds based on the structure of goniothalamin, a natural styryl lactone which has been found to display cytotoxic and antiproliferative activities against a variety of cancer cell lines. A focused library of 29 novel goniothalamin analogues was prepared and evaluated against seven human cancer cell lines. While the γ-pyrones and the aza-goniothalamin analogues were less potent than the lead compound, 2,4-dimethoxy analogue 88 has shown to be more potent in vitro than goniothalamin against all cancer cell lines evaluated. Furthermore, it was more potent than doxorubicin against NCI-ADR/RES, OVCAR-03 and HT-29 while being less toxic to human keratinocytes (HaCat). The 3,5-dimethoxy analogue 90 and 2,4,5-trimethoxy analogue 92 also displayed promising antiproliferative activity when compared to goniothalamin (1). These results provide new elements for the design and synthesis of novel representatives of this family of natural compounds. © 2012 Elsevier Ltd. All rights reserved.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2012.03.059
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84861198518&partnerID=40&md5=1b91f27adc1093663492f21476da7971
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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