Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/97237
Type: Artigo de periódico
Title: Optimizing Sln And Nlc By 2 2 Full Factorial Design: Effect Of Homogenization Technique
Author: Severino P.
Santana M.H.A.
Souto E.B.
Abstract: Solid lipid nanoparticles (SLN) and nanostructured lipid carrier (NLC) have been employed in pharmaceutics and biomedical formulations. The present study focuses on the optimization of the production process of SLN and NLC by High Shear Homogenization (HSH) and High Pressure Homogenization (HPH). To build up the surface response charts, a 2 2 full factorial design based on 2 independent variables was used to obtain an optimized formulation. The effects of the production process on the mean particle size, polydispersity index (PI) and zeta potential (ZP) were investigated. Optimized SLN were produced applying 20,000 rpm HSH and 500 bar HPH pressure and NLC process 15,000 rpm HSH and 700 bar HPH pressure, respectively. This factorial design study has proven to be a useful tool in optimizing SLN (~ 100 nm) and NLC (~ 300 nm) formulations. The present results highlight the benefit of applying statistical designs in the preparation of lipid nanoparticles. © 2012 Elsevier B.V.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.msec.2012.04.017
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84861874569&partnerID=40&md5=d200c19dbafe76813f52cb1f6524f289
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.