Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/97155
Type: Artigo de periódico
Title: Klinefelter Syndrome: An Unusual Diagnosis In Pediatric Patients
Author: Tincani B.J.
Mascagni B.R.
Pinto R.D.P.
Guaragna-Filho G.
Castro C.C.T.S.
Sewaybricker L.E.
Viguetti-Campos N.L.
Marques-de-Faria A.P.
Maciel-Guerra A.T.
Guerra Jr. G.
Abstract: Objective: To identify clinical and laboratory data which differentiate Klinefelter syndrome (KS) patients according to age group. Methods: The study included all cases of hypogonadism, gynecomastia and/or infertility whose karyotype was performed at a university hospital from January 1989 to December 2011, in a total of 105 subjects. The following data were retrospectively analyzed: age at first visit, ratio of arm span to height, pubic hair, gynecomastia, testicular volume, luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone (T), and sperm analysis. Results: During the study period, 33 patients were diagnosed with Klinefelter syndrome (KS+) and 72 were not (KS-). Out of all KS cases, only seven (21.2%) were diagnosed before 20 years old and two (6.1%) before 10 years old. Age at first consultation (in years) was similar in both groups (KS+ = 31.3±12.9 and KS- = 27.6±12.1), as were ratio of arm span to height and frequency of gynecomastia. However, in KS+ patients, pubic hair was less developed, testicular volume was smaller and testosterone levels were lower, while LH and FSH levels and frequency of azoospermia were higher. Conclusions: Klinefelter syndrome is both an under and late diagnosed condition. The most important data for diagnosis are testicular volume, hormone levels and presence of azoospermia in sperm analysis, especially in puberty and adult life. Copyright © by Sociedade Brasileira de Pediatria.
Editor: 
Rights: aberto
Identifier DOI: 10.2223/JPED.2208
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84865998617&partnerID=40&md5=bb2b192305b5cb978c5804f5f3e7042b
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.