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Type: Artigo de periódico
Title: Levels And Patterns Of Expression Of Hypoxia-inducible Factor-1α, Vascular Endothelial Growth Factor, Glucose Transporter-1 And Cd105 In Adenoid Cystic Carcinomas With High-grade Transformation
Author: Costa A.F.
Tasso M.G.
Mariano F.V.
Soares A.B.
Chone C.T.
Crespo A.N.
Fresno M.F.
Llorente J.L.
Suarez C.
de Araujo V.C.
Hermsen M.
Altemani A.
Abstract: Aims: To compare the expression of proteins regulated by hypoxia between adenoid cystic carcinoma (ACC) with and without high-grade transformation (HGT). Methods and results: In eight ACC-HGT and 18 ACC without HGT, expression of hypoxia-inducible factor-1 (HIF-1α), vascular endothelial growth factor (VEGF), glucose transporter-1 (GLUT-1) and microvascular density (MVD) by CD105 (a hypoxia-inducible protein expressed in angiogenic endothelial cells) was determined. Expression levels of HIF-1α and VEGF as well as CD105-MVD did not differ significantly between: (i) transformed and conventional areas (TA and CA, respectively) of ACC-HGT, (ii) CA and ordinary ACC. HIF-1α was detected in 100% of cases and presented a diffuse expression pattern. No significant association was found between levels of HIF-1α expression and tumour size, metastasis and recurrence. GLUT-1 showed a prostromal expression pattern and was observed exclusively in TA (three of six cases) and in only three of 14 ACC. Conclusions: Both the absence of significant alterations in levels of expression of HIF-1α, VEGF and CD105 and the patterns of expression of HIF-1α and GLUT-1 suggest that hypoxia may not play a key role in the process of high-grade transformation of ACC. Although HIF-1α expression is a common finding in ACC, it cannot be used as a marker of tumour aggressiveness. © 2012 Blackwell Publishing Limited.
Rights: fechado
Identifier DOI: 10.1111/j.1365-2559.2011.04128.x
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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