Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/96975
Type: Artigo de periódico
Title: Cost-effectiveness And Budget Impact Of Saxagliptine As Additional Therapy To Metformin For The Treatment Of Diabetes Mellitus Type 2 In The Brazilian Private Health System
Author: Nita M.E.
Eliaschewitz F.G.
Ribeiro E.
Asano E.
Barbosa E.
Takemoto M.
Donato B.
Rached R.
Rahal E.
Abstract: Objectives: To compare costs and clinical benefits of three additional therapies to metformin (MF) for patients with diabetes mellitus type 2 (DM2). Methods: A discrete event simulation model was built to estimate the cost-utility ratio (cost per quality-adjusted life years [QALY]) of saxagliptine as an additional therapy to MF when compared to rosiglitazone or pioglitazone. A budget impact model (BIM) was built to simulate the economic impact of saxagliptine use in the context of the Brazilian private health system. Results: The acquiring medication costs for the hypothetical patient group analyzed in a time frame of three years were R$10,850,185, R$14,836,265 and R$ 14,679,099 for saxagliptine, pioglitazone and rosiglitazone, respectively. Saxagliptine showed lower costs and greater effectiveness in both comparisons, with projected savings for the first three years of R$ 3,874 and R$3,996, respectively. The BIM estimated cumulative savings of R$417,958 with the repayment of saxagliptine in three years from the perspective of a health plan with 1,000,000 covered individuals. Conclusion: From the perspective of private paying source, the projection is that adding saxagliptine with MF save costs when compared with the addition of rosiglitazone or pioglitazone in patients with DM2 that have not reached the HbA1c goal with metformin monotherapy. The BIM of including saxagliptine in the reimbursement lists of health plans indicated significant savings on the three-year horizon. © 2012 Elsevier Editora Ltda. All right reserved.
Editor: 
Rights: fechado
Identifier DOI: 10.1590/S0104-42302012000300008
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84864843720&partnerID=40&md5=00d65a29e63bd97ff44008ce2f700371
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.