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|Type:||Artigo de periódico|
|Title:||Experimental Model Of Smoking And Simulation Of Reflux With Acid And Pepsin In Rats [modelo Experimental De Tabagismo E Simulação De Refluxo Com ácido E Pepsina Em Ratos]|
|Author:||Zen Jr. J.H.|
del Negro A.
|Abstract:||PURPOSE: To develop experimental models to evaluate the effects of hydrochloric acid associated with the pepsin instilled in the mucosa of the upper esophagus and the sophagogastric junction of young male rats Wistar, simulating injury caused by astroesophageal reflux on the mucosa of aero-digestive tract in humans as well as the action of the risk exposure of mucosa to cigarette smoke. METHODS: Fifty young male Wistar rats divided in 5 groups with 10 animals each one, respectively simulating pharyngo-laryngeal reflux and gastroesophageal reflux, pharyngo-laryngeal reflux and smoking, smoking only, astroesophageal reflux and control group. RESULTS: The histopathologic studies no recorded neoplasias, only mild changes and no significant alterations. The hemo-oximetry (carboxyhemoglobin and methemoglobim) and CO2 concentration confirm that the animals were submitted to high intensity of exposure to carcinogens in tobacco and its derivatives. CONCLUSION: The experimental models were highly efficient, practical, easy to use and economical and can be employed in other similar studies to determine the harmful effects by smoking and reflux.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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