Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/96852
Type: Artigo de periódico
Title: Muscle Reinnervation In One Or Two Stages? Experimental Study In Rats With End-to-side Nerve Graft [reinervação Muscular Em Um Ou Dois Estágios? Estudo Experimental Em Ratos Com Enxerto De Nervo Término-lateral]
Author: Bersaneti J.A.
Viterbo F.
Jorge J.
Denadai R.
Abstract: Purpose: To compare muscle reinnervation in one and two surgical stages using end-to-side neurorrhaphy (ESN) without donor nerve injury. Methods: The experiment was performed on four groups of 20 rats. Group 1 (G1), one stage, received the graft which was sutured to the tibial nerve, with ESN, and its free stump was sutured end-to-end to the distal stump of the sectioned peroneal nerve (PN), all in the same operation. In Group 2 (G2), two stages, the nerve graft was sutured to the tibial nerve, with ESN. Two months later the PN was sectioned and its distal stump connected to the distal stump of the graft as in G1. Normal control group (Gn) received the graft only sutured to the tibial nerve, with ESN. Denervated control group (Gd), as well received the graft and had the PN sectioned and its two stumps buried in adjacent musculature, with the aim of denervating the cranial tibial muscle (CTM), the target of this study. The parameters used to evaluate CTM reinnervation were muscle mass, muscle fiber's minimum diameter and area. Results: The mean CTM mass, the average of the muscular fibers areas and the average of the muscular fiber minimum diameters was higher (all p<0.0001) in G2 than in G1. Comparing the four groups, these parameters had their maximum expression in Gn and the minimum in Gd, as expected. Conclusion: The two stages showed better muscle reinnervation than one stage.
Editor: 
Rights: aberto
Identifier DOI: 10.1590/S0102-86502012001200003
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84870882339&partnerID=40&md5=6a4425db136d8fa564072af8d1c0a9df
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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