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|Type:||Artigo de periódico|
|Title:||Resolution Of Ibuprofen: A Project For An Experimental Organic Chemistry Course [resolução Do Ibuprofeno: Um Projeto Para Disciplina De Química Orgânica Experimental]|
|Abstract:||A practical and didactic sequence of experiments was proposed to illustrate the stereochemistry concept, optically active compounds, resolution of racemates, and use of the NMR technique, including 2D-COSY for identification of organic compounds, on a laboratory course for undergraduate students. The sequence was: extractions of racemic ibuprofen and chiral naproxen from commercial tablets; syntheses of diastereoisomeric amides reacting chiral (S)-(-)-a-methylbenzylamine with (±)-ibuprofen; separation and determination of absolute configuration of amides by 1H NMR spectroscopy and GC analysis, and hydrolysis of amides to obtain (+)- and (-)-ibuprofen.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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