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Type: Artigo de periódico
Title: Resolution Of Ibuprofen: A Project For An Experimental Organic Chemistry Course [resolução Do Ibuprofeno: Um Projeto Para Disciplina De Química Orgânica Experimental]
Author: Romero A.L.
Baptistella L.H.B.
Coelho F.
Imamura P.M.
Abstract: A practical and didactic sequence of experiments was proposed to illustrate the stereochemistry concept, optically active compounds, resolution of racemates, and use of the NMR technique, including 2D-COSY for identification of organic compounds, on a laboratory course for undergraduate students. The sequence was: extractions of racemic ibuprofen and chiral naproxen from commercial tablets; syntheses of diastereoisomeric amides reacting chiral (S)-(-)-a-methylbenzylamine with (±)-ibuprofen; separation and determination of absolute configuration of amides by 1H NMR spectroscopy and GC analysis, and hydrolysis of amides to obtain (+)- and (-)-ibuprofen.
Rights: aberto
Identifier DOI: 
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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