Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/96733
Type: Artigo de periódico
Title: Resolution Of Ibuprofen: A Project For An Experimental Organic Chemistry Course [resolução Do Ibuprofeno: Um Projeto Para Disciplina De Química Orgânica Experimental]
Author: Romero A.L.
Baptistella L.H.B.
Coelho F.
Imamura P.M.
Abstract: A practical and didactic sequence of experiments was proposed to illustrate the stereochemistry concept, optically active compounds, resolution of racemates, and use of the NMR technique, including 2D-COSY for identification of organic compounds, on a laboratory course for undergraduate students. The sequence was: extractions of racemic ibuprofen and chiral naproxen from commercial tablets; syntheses of diastereoisomeric amides reacting chiral (S)-(-)-a-methylbenzylamine with (±)-ibuprofen; separation and determination of absolute configuration of amides by 1H NMR spectroscopy and GC analysis, and hydrolysis of amides to obtain (+)- and (-)-ibuprofen.
Editor: 
Rights: aberto
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84866283027&partnerID=40&md5=522730b3d355f80751a1291560031886
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.