Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/96730
Type: Artigo de periódico
Title: Chemical Study Of Sinningia Allagophylla Guided By Antiproliferative Activity Assays [estudo Químico De Sinningia Allagophylla Guiado Por Testes De Atividade Antiproliferativa]
Author: Riva D.
Barison A.
Stefanello M.E.A.
Poliquesi C.B.
Ruiz A.L.T.G.
De Carvalho J.E.
Salvador M.J.
Abstract: Activity guided fractionation of Sinningia allagophylla (Mart.) Wiehler ethanolic extract yielded a new benzochromene 8-methoxylapachenol, besides seven known compounds: lapachenol, sitosteryl oleate, sitosteryl linoleate, stigmasteryl oleate, stigmasteryl linoleate, dunniol and tectoquinone. Extract, fractions, and compounds lapachenol, 8-methoxylapachenol, and dunniol were tested in vitro against human cancer cell lines U251 (glioma, CNS), MCF-7 (breast), NCI-ADR/RES (drug-resistant ovarian), 786-0 (kidney), NCI-H460 (lung, no small cells), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon), K562 (leukemia) and against VERO, a normal cell line. The most active compound was dunniol, which inhibited the growth of U251, MCF-7, NCI-ADR/RES, OVCAR-3 and K562 cell lines.
Editor: 
Rights: aberto
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84864193817&partnerID=40&md5=8a7244b666477ae768bdf17cebd794b8
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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