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Type: Artigo de periódico
Title: Fast Determination Of Basic Drugs In Plasma By Gas Chromatography With Nitrogen Phosphorus Detector [determinação Rápida De Fármacos Básicos Em Plasma Por Cromatografia A Gás Com Detector De Nitrogênio E Fósforo]
Author: Lizot L.F.
Da Silva L.L.
Spaniol B.
Antunes M.V.
Linden R.
Lanaro R.
Abstract: A simple and fast method for determination of 40 basic drugs in human plasma employing gas-chromatography with nitrogen-phosphorus detection was developed and validated. Drugs were extracted from 800 ?L of plasma with 250 ?L of butyl acetate at basic pH. Aliquots of the organic extract were directly injected on a column with methylsilicone stationary phase. Total chromatographic run time was 25 min. All compounds were detected in concentrations ranging from therapeutic to toxic levels, with intermediate precision CV% below 11.2 and accuracy in the range of 92-114%.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422012000600029
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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