Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/96633
Type: Artigo de periódico
Title: Reproductive Physiology And Physical And Sexual Development Of Female Offspring Born To Diabetic Dams [desenvolvimento Físico, Sexual E Fisiologia Reprodutiva Da Prole Feminina De Ratas Diabéticas]
Author: Spadotto R.
Damasceno D.C.
Godinho A.F.
Amorim E.M.P.
Perobelli J.E.
Kempinas W.G.
Abstract: Objectives: The objective of this study was to evaluate physical and sexual development and reproductive physiology in female rat offspring that developed in hyperglycemia conditions in utero and during lactation. Materials and methods: Maternal diabetes was induced in female rats by a single IV injection of streptozotocin before mating. Female offspring development was evaluated by means of the following parameters: physical development; age of vaginal opening and first estrus; weight and histological evaluation of uterus and ovaries; duration of the estrous cycle, sexual behavior, and fertility after natural mating. Results: In the female offspring, maternal diabetes caused delays in initial physical development; diminution in ovary weight and number of follicles; and inferior reproductive performance compared with the control group. Conclusions: The exposure to hyperglycemia in uterus and during lactation caused delays in physical and sexual development, and affected the reproductive physiology of female rats negatively. © ABE&M todos os direitos reservados.
Editor: 
Rights: aberto
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84861314620&partnerID=40&md5=db88d16d0bcc1e4c40790e76a7ecd6a8
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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