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Type: Artigo de periódico
Title: Are Skeletally Mature Female Rats A Suitable Model To Study Osteoporosis? [ratas Esqueleticamente Maduras São Um Modelo Satisfatório Para Estudar Osteoporose?]
Author: Netto C.C.
Vieira V.C.C.
Marinheiro L.P.F.
Agellon S.
Weiler H.
Marostica Jr. M.R.
Abstract: Objective: To analyze if female Wistar rats at 56 weeks of age are a suitable model to study osteoporosis. Materials and methods: Female rats with 6 and 36 weeks of age (n = 8 per group) were kept over a 20-week period and fed a diet for mature rodents complete in terms of Ca, phosphorous, and vitamin D. Excised femurs were measured for bone mass using dual-energy x-ray absorptiometry, morphometry, and biomechanical properties. The following serum mar kers of bone metabolism were analyzed: parathyroid hormone (PTH), osteocalcin (OC), osteoprotegerin (OPG), receptor activator of nuclear factor κappa B ligand (RANKL), C-terminal peptides of type I collagen (CTX-I), total calcium, and alkaline phosphatase (ALP) activity. Results: Rats at 56 weeks of age showed important bone metabolism differences when compared with the younger group, such as, highest diaphysis energy to failure, lowest levels of OC, CTX-I, and ALP, and elevated PTH, even with adequate dietary Ca. Conclusion: Rats at 26-week-old rats may be too young to study age-related bone loss, whereas the 56-week-old rats may be good models to represent the early stages of age-related changes in bone metabolism. © ABE&M todos os direitos reservados.
Rights: aberto
Identifier DOI: 10.1590/S0004-27302012000400007
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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