Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/966
Type: Artigo de periódico
Title: Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo
Author: LOPES, Stefanie C. P.
BLANCO, Yara C.
JUSTO, Giselle Z.
NOGUEIRA, Paulo A.
RODRIGUES, Francisco L. S.
GOELNITZ, Uta
WUNDERLICH, Gerhard
FACCHINI, Gustavo
BROCCHI, Marcelo
DURAN, Nelson
COSTA, Fabio T. M.
Abstract: Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.
Country: Estados Unidos
Editor: AMER SOC MICROBIOLOGY
Citation: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v.53, n.5, p.2149-2152, 2009
Rights: fechado
Identifier DOI: 10.1128/AAC.00693-08
Address: http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000265528700060&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
http://dx.doi.org/10.1128/AAC.00693-08
Date Issue: 2009
Appears in Collections:IB - Artigos e Materiais de Revistas Científicas

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