Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/964
Type: Artigo de periódico
Title: Balanoposthitis caused by Pseudomonas aeruginosa co-producing metallo-beta-lactamase and 16S rRNA methylase in children with hematological malignancies
Author: LINCOPAN, Nilton
NEVES, Patricia
MAMIZUKA, Elsa M.
LEVY, Carlos E.
Abstract: Balanoposthitis is defined as the inflammation of the glans penis and its foreskin. In the presence of other underlying medical conditions, this localized infection may spread systemically, serving as a source of fever and bacteremia in neutropenic males. Two rare cases of balanoposthitis caused by a clonally related Pseudomonas aeruginosa isolate co-producing the SPM-1 metallo-beta-lactamase and the novel 16S rRNA methylase RmtD are described. Four multidrug-resistant (MDR) P. aeruginosa isolates were successively recovered from glans/foreskin swabs and urine cultures from two uncircumcised pediatric patients, one with Burkitt`s non-Hodgkin`s lymphoma and one with acute lymphoblastic leukemia. Clinically, preputial colonization by MDR P. aeruginosa evolved to severe balanoposthitis with glans/foreskin lesions as a source of fever. Combination therapy of ciprofloxacin and/or aztreonam (systemic) plus polymyxin B (topical) was effective once reversion of the neutropenic condition was achieved. Although P. aeruginosa remains an unusual cause of balanoposthitis, these cases should alert the physician to the potential pathogenicity of this bacterium. Furthermore, co-production of metallo-beta-lactamase and 16S rRNA methylase has a potential impact on the empirical management of complicated infections caused by P. aeruginosa. Crown Copyright (C) 2009 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. All rights reserved.
Subject: Balanitis
Multidrug-resistant
Pseudomonas aeruginosa
Neutropenic patients
Country: Inglaterra
Editor: ELSEVIER SCI LTD
Citation: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.14, n.4, p.E344-E347, 2010
Rights: fechado
Identifier DOI: 10.1016/j.ijid.2009.04.016
Address: http://dx.doi.org/10.1016/j.ijid.2009.04.016
http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000275794200012&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
Date Issue: 2010
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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